当前共找到 1188 篇文献分享,本页显示第 61 - 80 篇。
61.
刘昊辰 (2025-01-24 14:04):
#paper Proof Number Based Monte-Carlo Tree Search. 这篇论文提出了 PN-MCTS 算法,将蒙特卡洛树搜索(MCTS)和证明数搜索(PNS)相结合,通过在多个游戏领域实验,验证了该算法在部分游戏上相比传统 MCTS 的优势,为游戏搜索算法改进提供了新方向。下载地址:https://arxiv.org/pdf/2303.09449
arXiv, 2023-03-16T16:27:07Z. DOI: 10.48550/arXiv.2303.09449
Abstract:
This paper proposes a new game-search algorithm, PN-MCTS, which combinesMonte-Carlo Tree Search (MCTS) and Proof-Number Search (PNS). These twoalgorithms have been successfully applied for decision making in a range ofdomains. … >>>
This paper proposes a new game-search algorithm, PN-MCTS, which combinesMonte-Carlo Tree Search (MCTS) and Proof-Number Search (PNS). These twoalgorithms have been successfully applied for decision making in a range ofdomains. We define three areas where the additional knowledge provided by theproof and disproof numbers gathered in MCTS trees might be used: final moveselection, solving subtrees, and the UCB1 selection mechanism. We test allpossible combinations on different time settings, playing against vanilla UCTon several games: Lines of Action ($7$$\times$$7$ and $8$$\times$$8$ boardsizes), MiniShogi, Knightthrough, and Awari. Furthermore, we extend this newalgorithm to properly address games with draws, like Awari, by adding anadditional layer of PNS on top of the MCTS tree. The experiments show thatPN-MCTS is able to outperform MCTS in all tested game domains, achieving winrates up to 96.2% for Lines of Action. <<<
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62.
颜林林 (2025-01-18 12:14):
#paper doi:10.1016/j.ajhg.2024.12.013, The American Journal of Human Genetics, 2025, HiFi long-read genomes for difficult-to-detect, clinically relevant variants. 这篇文献来自PacBio,选取了100例病例,这些病例都携带有已知致病性胚系突变,且这些突变都难以在短读长测序中被检测,但已经经由其他诸如PCR、MLPA等各类方法确认过。使用长读长测序(LRS,PacBio HiFi)检测,其中93%的突变能够被测到(83%的突变能够在分析流程中被报出,而10%通过人工复核数据能够看到相应信号)。据此,说明LRS作为一种有前景的单一技术,可以用于罕见疾病的诊断。
63.
惊鸿 (2025-01-15 18:01):
#paper Mitotic lethality prevents inflammation Pub Date : 2025-01-14 DOI : 10.1038/s41556-024-01529-1 现在一项研究发现,DNA 损伤后,通过同源重组修复 DNA 会驱动有丝分裂过程中非免疫原性细胞死亡。同源重组的缺失使细胞能够通过有丝分裂,但会驱动间期死亡和炎症。这表明免疫原性和非免疫原性细胞死亡模式之间存在二分法,具有生物医学潜力。
64.
龙海晨 (2025-01-15 10:46):
#paper Meecham A, Marshall JF. The ITGB6 gene: its role in experimental and clinical biology. Gene X. 2019 Nov 6;5:100023. doi: 10.1016/j.gene.2019.100023. PMID: 32550552; PMCID: PMC7285966. 这是一篇关于ITGB6 基因在临床生物和实验方面的综述。包括其结构、转录和转录后调控、在ITGB6缺陷小鼠中观察到的生物学效应以及ITGB6突变的临床病例。结合文献发现尽管已经进行了大量的工作来确定ITGB6基因的结构,但关于 β6 蛋白表达是如何调节的,还有许多未解答的问题。
65.
DeDe宝 (2025-01-02 14:18):
#paper DOI: 10.1016/j.neuron.2017.12.020 The brain compass: a perspective on how self-motion updates the head direction cell attractor 这篇研究探讨了大脑中的方向细胞(head direction cells)。方向细胞构成了一个内部指南针,即使在没有视觉地标的情况下也能工作。这些方向细胞的活动由神经元环吸引子(neuronal ring attractor)产生,并通过旋转速度信号更新。研究者提出了一个定量框架,解释这些旋转速度信号是如何表示一个多感官自我运动估计,并通过内部模型使用前庭、视觉和触觉感官的预测误差更新。该模型基于Kalman滤波器,将被动前庭信号处理的内部模型框架扩展到主动头部运动,并结合了运动类型(主动或者被动)。研究发现,头部方向细胞的放电率在自由觅食和被动旋转两种运动情况中存在差异,且这种差异可以通过吸引子内部的递归连接强度来解释。研究还总结了重力影响方位编码的最新发现,作者提出内部指南针可能是三维的,并假设额外的垂直自由度使用全局(而非自我框架的)的全局重力线索。
66.
翁凯 (2025-01-01 01:23):
#paper DOI: 10.1038/s41467-024-52615-9. Nature Communications, 2024. The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer. 这篇论文探索了女性胃癌往卵巢的转移在绝经前高发的机制。主要利用单细胞转录组技术,作者发现绝经前女性的雌激素和雌激素受体(ER)水平较高,而雌激素在卵巢转移中起到了关键的促进作用。具体来说,卵巢成纤维细胞表达高水平的ER,并且在雌激素的刺激下,这些成纤维细胞分泌Midkine(MDK),而MDK通过与低密度脂蛋白受体相关蛋白1(LRP1)结合,促进胃癌细胞的迁移和侵袭,从而增强了卵巢转移的能力。
67.
林海onrush (2025-01-01 00:27):
#paper, doi: https://doi.org/10.48550/arXiv.2305.19229 ,FedDisco: Federated Learning with Discrepancy-Aware Collaboration, AI顶会ICML上的一篇联邦学习文章,这篇论文提出了一种新的联邦学习(Federated Learning, FL)方法,称为 FedDisco,用于解决数据异质性问题,特别是类别分布的差异性。传统联邦学习通常根据客户端数据集的大小分配模型聚合权重,但这种方法无法充分反映客户端数据的类别分布差异,导致全局模型优化性能不足。FedDisco 引入了一种“差异感知”的聚合权重计算方式,将客户端的数据集大小和本地与全局类别分布的差异程度结合起来,通过调整聚合权重优化全局模型。这一方法在保持隐私保护的前提下,提高了通信和计算效率,并通过理论分析证明了其能有效收紧优化误差上界,从而改善全局模型性能。 实验表明,FedDisco 在多种异质性场景和数据集上显著优于现有的联邦学习方法,且其模块化设计可以轻松整合到现有方法中以进一步提升性能。此外,该方法在仅部分客户端参与的场景和文本分类任务中也表现出良好的适用性。FedDisco 的关键优势在于其创新的聚合权重分配策略,能够在低计算和通信开销下,提升联邦学习算法的鲁棒性和泛化能力。
arXiv, 2023-05-30T17:20:51Z. DOI: 10.48550/arXiv.2305.19229
Abstract:
This work considers the category distribution heterogeneity in federatedlearning. This issue is due to biased labeling preferences at multiple clientsand is a typical setting of data heterogeneity. To alleviate this … >>>
This work considers the category distribution heterogeneity in federatedlearning. This issue is due to biased labeling preferences at multiple clientsand is a typical setting of data heterogeneity. To alleviate this issue, mostprevious works consider either regularizing local models or fine-tuning theglobal model, while they ignore the adjustment of aggregation weights andsimply assign weights based on the dataset size. However, based on ourempirical observations and theoretical analysis, we find that the dataset sizeis not optimal and the discrepancy between local and global categorydistributions could be a beneficial and complementary indicator for determiningaggregation weights. We thus propose a novel aggregation method, FederatedLearning with Discrepancy-aware Collaboration (FedDisco), whose aggregationweights not only involve both the dataset size and the discrepancy value, butalso contribute to a tighter theoretical upper bound of the optimization error.FedDisco also promotes privacy-preservation, communication and computationefficiency, as well as modularity. Extensive experiments show that our FedDiscooutperforms several state-of-the-art methods and can be easily incorporatedwith many existing methods to further enhance the performance. Our code will beavailable at https://github.com/MediaBrain-SJTU/FedDisco. <<<
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68.
半面阳光 (2024-12-31 22:15):
#paper DOI: https://doi.org/10.1038/s41598-017-02031-5. Sci Rep 2017, Novel Algorithms for Improved Sensitivity in Non-Invasive Prenatal Testing. 这篇文章介绍了作者团队开发的旨在提升NIPT检测灵敏性和特异性的三种算法,分别是 the chi-squared-based variation reduction (χ2VR)、the regression-based Z-score (RBZ)、the Match QC score。其中The χ2VR算法用于减少样本之间每条染色体所比对上的reads数的差异,RBZ算法用于染色体三体的预测,Match QC score用于反应对照组对特定的样本是否具有代表性。此外,还将这些算法与NIPT检测中常用的算法的检测效果进行了比较。结果显示χ2VR 和 RBZ 都对减少变异性有帮助,进而提升NIPT检测灵敏性。该研究还发现一个最有的算法组合是在分析的预处理过程中使用常用的GC correction方法 和 χ2VR方法,在染色体三体预测流程中使用RBZ方法。
Abstract:
AbstractNon-invasive prenatal testing (NIPT) of cell-free DNA in maternal plasma, which is a mixture of maternal DNA and a low percentage of fetal DNA, can detect fetal aneuploidies using massively … >>>
AbstractNon-invasive prenatal testing (NIPT) of cell-free DNA in maternal plasma, which is a mixture of maternal DNA and a low percentage of fetal DNA, can detect fetal aneuploidies using massively parallel sequencing. Because of the low percentage of fetal DNA, methods with high sensitivity and precision are required. However, sequencing variation lowers sensitivity and hampers detection of trisomy samples. Therefore, we have developed three algorithms to improve sensitivity and specificity: the chi-squared-based variation reduction (χ2VR), the regression-based Z-score (RBZ) and the Match QC score. The χ2VR reduces variability in sequence read counts per chromosome between samples, the RBZ allows for more precise trisomy prediction, and the Match QC score shows if the control group used is representative for a specific sample. We compared the performance of χ2VR to that of existing variation reduction algorithms (peak and GC correction) and that of RBZ to trisomy prediction algorithms (standard Z-score, normalized chromosome value and median-absolute-deviation-based Z-score). χ2VR and the RBZ both reduce variability more than existing methods, and thereby increase the sensitivity of the NIPT analysis. We found the optimal combination of algorithms was to use both GC correction and χ2VR for pre-processing and to use RBZ as the trisomy prediction method. <<<
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69.
符毓 Yu (2024-12-31 21:56):
#paper doi:10.1109/CBS.2017.8266084 2017 IEEE International Conference on Cyborg and Bionic Systems (CBS), 2017, Electromagnetic design of a high torque density permanent magnet motor for biomimetic robot. 实现更快仿生机器人目标的限制因素是驱动机器人的电机产生的扭矩,以及这些电机的质量和功耗。这些限制决定了需要一种低质量大扭矩的电机。为了提高电机的扭矩密度,本文概述了一种分数槽集中绕组永磁无刷直流电机的电磁设计,以满足机器人的目标,同时最小化总质量。分析了分数槽集中绕组电机的极槽数组合依据,并根据永磁场和气隙场计算了电机由永磁体和绕组电流产生的磁场。此外,对电机进行了有限元分析,研究了磁场分布、反电动势、铁损、稳态扭矩和齿槽扭矩。结果证明了设计方法的可行性,电机的扭矩密度为3.47Nm/kg。高于国际主流商用电机参数
70.
盼盼 (2024-12-31 21:44):
#paper doi:10.1097/HEP.0000000000001201 2024年12月,Hepatology在线发表了最新研究成果“Lhx2 specifically expressed in hepatic stellate cells promotes liver regeneration and inhibits liver fibrosis”,该研究通过比较小鼠急性和慢性肝损伤模型,结合RNA-seq和单细胞RNA-seq数据分析,发现Lhx2在肝星状细胞中特异性表达,具有促进肝脏再生和抑制纤维化的双重功能。hx2能够通过上调SMAD6阻断TGF-β信号通路,抑制HSCs的激活,同时促进肝细胞生长因子HGF的表达,加速肝细胞增殖。这一发现为开发治疗肝脏疾病的新策略提供了潜在靶点,具有重要的临床意义。
Abstract:
Background and Aims: Promoting liver regeneration while inhibiting fibrogenesis represented an attractive strategy for treating liver diseases, with hepatic stellate cells (HSCs) being crucial to both processes. This study aimed … >>>
Background and Aims: Promoting liver regeneration while inhibiting fibrogenesis represented an attractive strategy for treating liver diseases, with hepatic stellate cells (HSCs) being crucial to both processes. This study aimed to identify specific targets in HSCs that simultaneously facilitated regeneration and suppressed fibrosis, and elucidated their molecular mechanisms. Approach and Results: Through comparing acute and chronic liver injury mouse models induced by CCl4 injections, we revealed that HSCs exhibited dual functionality, expressing pro-regenerative and pro-fibrogenic genes following injury. Analyzing RNA-seq data from primary HSCs of these models, along with publicly available single-cell RNA-seq data of HSCs, we identified transcription factor Lhx2, specifically expressed in HSCs, emerged as a potential regulator of the dual functions. Notably, Lhx2 showed significantly higher expression in HSCs from healthy liver tissue compared to fibrotic liver, in both mouse and human models. Lhx2 knockdown impaired liver function recovery and cellular proliferation after acute liver injury. Consistent changes were observed in mice with HSC-specific Lhx2 overexpression. Additionally, Lhx2 overexpression not only promoted hepatocyte proliferation but also exhibited an anti-fibrogenic function after chronic injury. Mechanistically, Lhx2 suppressed multiple functions of activated HSCs, including fibrogenesis, proliferation and migration, and up-regulated SMAD6 to block TGF-β signaling pathway. Moreover, Lhx2 was an upstream regulator of various pro-regenerative factors, especially HGF, which is crucial for liver regeneration. Conclusions: We demonstrated that Lhx2 had pro-regenerative and anti-fibrogenic functions, and elucidated its regulatory mechanism. The study provided a potential target with dual effects for treating liver diseases. <<<
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71.
muton (2024-12-31 21:21):
#paper Jaffe PI, Poldrack RA, Schafer RJ, Bissett PG. Modelling human behaviour in cognitive tasks with latent dynamical systems. Nat Hum Behav. 2023 Jun;7(6):986-1000. doi: 10.1038/s41562-022-01510-8. Epub 2023 Jan 19. PMID: 36658212. 这篇文章介绍了一种名为 task-DyVA 的深度学习框架,它能够模拟人类在认知任务中的行为,特别是任务切换(task-switching)行为。task-DyVA 是基于动态变分自编码器(dynamical variational autoencoders)的框架,它结合了循环神经网络(RNN)的表现力和捕捉个体差异的能力。每个模型直接约束于复现单个参与者的反应时间序列。模型通过训练来模拟人类在认知任务中的实时行为。模型的潜在动态系统能够捕捉执行任务所需的所有内部认知操作。总的来说,这篇文章提出了一种新的方法来模拟和理解人类在复杂认知任务中的行为动态,为认知科学和神经科学的研究提供了新的工具和视角。
72.
前进 (2024-12-31 20:09):
#paper DOI 10.48550/arXiv.2111.06377 He, K., Chen, X., Xie, S., Li, Y., Doll'ar, P., & Girshick, R. B. (2021). Masked Autoencoders Are Scalable Vision Learners. In 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) 本文提出了一种创新的自监督学习框架器(MAE)。该方法的核心创新在于采用随机遮蔽策略,仅利用图像中未被遮蔽的25%像素来重建整个图像,从而迫使模型学习到更有效的视觉特征。此外,MAE采用非对称的编码器-解码器架构。使用一个编码器,仅处理未被遮蔽的图像部分,以及一个轻量级的解码器,它从编码器的输出和遮蔽部分的位置信息中重建原始图像。大幅降低了计算成本,提高了训练效率。实验结果表明,MAE在自监督预训练方面具有出色的泛化能力,可应用于多种下游任务,且具备良好的可扩展性。
arXiv, 2021-11-11T18:46:40Z. DOI: 10.48550/arXiv.2111.06377
Abstract:
This paper shows that masked autoencoders (MAE) are scalable self-supervisedlearners for computer vision. Our MAE approach is simple: we mask randompatches of the input image and reconstruct the missing pixels. … >>>
This paper shows that masked autoencoders (MAE) are scalable self-supervisedlearners for computer vision. Our MAE approach is simple: we mask randompatches of the input image and reconstruct the missing pixels. It is based ontwo core designs. First, we develop an asymmetric encoder-decoder architecture,with an encoder that operates only on the visible subset of patches (withoutmask tokens), along with a lightweight decoder that reconstructs the originalimage from the latent representation and mask tokens. Second, we find thatmasking a high proportion of the input image, e.g., 75%, yields a nontrivialand meaningful self-supervisory task. Coupling these two designs enables us totrain large models efficiently and effectively: we accelerate training (by 3xor more) and improve accuracy. Our scalable approach allows for learninghigh-capacity models that generalize well: e.g., a vanilla ViT-Huge modelachieves the best accuracy (87.8%) among methods that use only ImageNet-1Kdata. Transfer performance in downstream tasks outperforms supervisedpre-training and shows promising scaling behavior. <<<
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73.
哪有情可长 (2024-12-31 19:56):
#paper Engineering source–sink relations by prime editing confers heat-stress resilience in tomato and rice, Cell,doi.org/10.1016/j.cell.2024.11.005,该研究针对高温逆境导致的番茄落花落果、品质低下,水稻秃尖、瘪壳等引起主要粮食和蔬菜作物大幅减产的农业生产实际问题,创建了环境智能高产稳产育种技术,该技术相当于给作物源库关系调控的关键枢纽基因安装一个温度感应器,赋予该基因实时感应温度变化自动优化源库分配的能力,创制了顺境高产逆境稳产的作物新种质。
74.
白鸟 (2024-12-31 14:20):
#paper doi:10.1038/s41588-024-01819-2 Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis. 这是一篇肺纤维化的空间转录组文献。文献基于前人单细胞文献的结果,对人患者IPF和小鼠BLM的肺部病变组织取样,分析病理纤维化生态位,探讨病变机制问题。 单细胞文献发现病变跟KRT5−/KRT17+基底细胞样 (AbBa) 上皮细胞群,Krt8+肺泡分化中间 (ADI) 细胞群有关。 文献的两个分析点是: 1.空转的分析非完全创新,而是基于单细胞的两类病变细胞群,在空间分析两类细胞与纤维化的关联; 2.Visium空转的一个鸡肋问题是:spot的细胞类型是混沌的,即使用单细胞的解卷积推测出来,也很难说明其准确性。 文献的核心是NMF非负矩阵因子,单个spot包含三层定义:NMF因子,手动病理注释,解卷积细胞类型推断;证明三层定义的一致性;能较好的规避单用解卷积推断偏差;后续的分析在此基础上进一步推断...
Abstract:
AbstractIdiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and limited treatment options. Efforts to identify effective treatments are thwarted by limited understanding of IPF pathogenesis and … >>>
AbstractIdiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and limited treatment options. Efforts to identify effective treatments are thwarted by limited understanding of IPF pathogenesis and poor translatability of available preclinical models. Here we generated spatially resolved transcriptome maps of human IPF (n = 4) and bleomycin-induced mouse pulmonary fibrosis (n = 6) to address these limitations. We uncovered distinct fibrotic niches in the IPF lung, characterized by aberrant alveolar epithelial cells in a microenvironment dominated by transforming growth factor beta signaling alongside predicted regulators, such as TP53 and APOE. We also identified a clear divergence between the arrested alveolar regeneration in the IPF fibrotic niches and the active tissue repair in the acutely fibrotic mouse lung. Our study offers in-depth insights into the IPF transcriptional landscape and proposes alveolar regeneration as a promising therapeutic strategy for IPF. <<<
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75.
钟鸣 (2024-12-31 12:59):
#paper doi:10.1128/iai.00346-24 A newly developed oral infection mouse model of shigellosis for immunogenicity and protective efficacy studies of a candidate vaccine 志贺氏菌感染引发消化系统疾病,对发展中国家构成重大的公共卫生挑战,本文开发了第一个通过口腔攻毒志贺氏菌建立感染的小鼠模型,方式是腹膜内注射去铁胺和氯化铁。作者通过攻毒,从大体病变、免疫系统改变、病理症状等角度验证了该模型的有效性及参考价值。随后还使用该模型验证了志贺氏菌侵袭蛋白侵袭质粒抗原 B (IpaB) 重组蛋白疫苗及嵌合重组疫苗 (rIpaB–T2544)(T2544是沙门氏菌外膜蛋白)的保护效果。
Abstract:
ABSTRACT Shigella infection poses a significant public health challenge in the developing world. However, lack of a widely available mouse model that replicates human shigellosis creates a major bottleneck to … >>>
ABSTRACT Shigella infection poses a significant public health challenge in the developing world. However, lack of a widely available mouse model that replicates human shigellosis creates a major bottleneck to better understanding of disease pathogenesis and development of newer drugs and vaccines. BALB/c mice pre-treated with streptomycin and iron (FeCl 3 ) plus desferrioxamine intraperitoneally followed by oral infection with virulent Shigella flexneri 2a resulted in diarrhea, loss of body weight, bacterial colonization and progressive colitis characterized by disruption of epithelial lining, loss of crypt architecture with goblet cell depletion, increased polymorphonuclear infiltration into the mucosa, submucosal swelling (edema), and raised proinflammatory cytokines and chemokines in the large intestine. To evaluate the usefulness of the model for vaccine efficacy studies, mice were immunized intranasally with a recombinant protein vaccine containing Shigella invasion protein invasion plasmid antigen B (IpaB). Vaccinated mice conferred protection against Shigella , indicating that the model is suitable for testing of vaccine candidates. To protect both Shigella and Salmonella , a chimeric recombinant vaccine (rIpaB–T2544) was developed by fusing IpaB with Salmonella outer membrane protein T2544. Vaccinated mice developed antigen-specific serum IgG and IgA antibodies and a balanced Th1/Th2 response and were protected against oral challenge with Shigella ( S. flexneri 2a , Shigella dysenteriae , and Shigella sonnei ) using our present mouse model and Salmonella ( Salmonella Typhi and Paratyphi) using an iron overload mouse model. We describe here the development of an oral S higella infection model in wild-type mouse. This model was successfully used to demonstrate the immunogenicity and protective efficacy of a candidate protein subunit vaccine against Shigella . <<<
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76.
小年 (2024-12-31 11:46):
#paper doi:10.1038/s41467-022-29336-y Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification. Nat Commun 13, 1640 (2022). 研究团队进行了中国儿童AML全基因组和转录组学研究,分析了驱动因子(突变特征)改变及其预后相关性,发现中国和西方儿童AML患者的基因突变谱存在显著差异。同时,研究人员提出了一种改进的预后风险分类模型,能够更好地反映中国儿童AML患者的不良事件风险。该研究强调了群体遗传背景在精准医学中的重要性。
Abstract:
AbstractStudies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML) based on Western populations. It is unknown to what extent the current genomic findings represent populations with different … >>>
AbstractStudies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML) based on Western populations. It is unknown to what extent the current genomic findings represent populations with different ethnic backgrounds. Here we present the genomic landscape of driver alterations of Chinese pediatric AML and discover previously undescribed genomic aberrations, including the XPO1-TNRC18 fusion. Comprehensively comparing between the Chinese and Western AML cohorts reveal a substantially distinct genomic alteration profile. For example, Chinese AML patients more commonly exhibit mutations in KIT and CSF3R, and less frequently mutated of genes in the RAS signaling pathway. These differences in mutation frequencies lead to the detection of previously uncharacterized co-occurring mutation pairs. Importantly, the distinct driver profile is clinical relevant. We propose a refined prognosis risk classification model which better reflected the adverse event risk for Chinese AML patients. These results emphasize the importance of genetic background in precision medicine. <<<
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77.
庞庞 (2024-12-29 21:58):
#paper doi: DOI: 10.1038/nn.4497 Dynamic models of large-scale brain activity 一篇对大脑动力学模型进行综述的文章,对于我这个初步接触该领域非常有用。文章首先简单介绍了动力学模型中的一些基本概念,比如state, attractors等等;然后介绍了如何对群体神经元进行建模:目前常基于NMM建模,然后根据结构关系(dmri数据)将其耦合到大脑介观尺度;最后探讨了如何验证建模的正确性。
78.
尹志 (2024-12-29 21:50):
#paper doi: 10.1021/acs.jcim.4c01107 Journal of Chemical Information and Modeling, 2024, Diffusion Models in De Novo Drug Design。又是一篇diffusion model用于药物设计的综述,很新很全面。这个领域的发展特别快,各种方法层出不穷,有了诺奖这次的加持,应该后面几年会有更多务实的成果。
79.
徐炳祥 (2024-12-29 17:05):
#paper doi: 10.1186/s12889-024-21045-z BMC Public Health, 2024, Effects of physical exercise on cardiorespiratory health of young adults during short-term exposure to varying air pollution levels。众所周知,暴露于空气污染环境下会损伤人体心肺机能,而开展体力活动有助于增强人体心肺机能,于是一个有意义的问题是这二者之间的交互作用为何,抑或在何种空气污染程度下进行体力活动可以抵消空气污染本身对心肺机能的影响。为此,本研究招募了30名健康青壮年志愿者在空气污染轻微、中等和严重三个级别下进行了一次性有氧运动训练,并从多个维度评定并对比了训练前后参与者的心肺机能情况。结果显示,在PM2.5≤115的轻度至中等污染环境中进行一小时中等强度有氧训练带给参与者心肺机能的收益足以覆盖暴露于此环境对心肺机能的损害,而在此之上的高浓度污染环境下则不能。本研究说明对健康青壮年,即使在空气不甚洁净时进行户外运动对心肺机能总体上仍然是安全的。
80.
李翛然 (2024-12-27 13:05):
#paper DOI: 10.1093/database/baaa102 NPBS database: a chemical data resource with relational data between natural products and biological sources. Database 2020, baaa102. 一个天然产物数据库,最近我在研究天然产物的一些方案,发现上海药物所把世界上主要的天然产物搞了个数据集,这个还是不错的。给大家也推荐一下, 但是搜索还是没做好,还是字符串相似度搜索,拉丁翻译和中文对应的比较差劲。 应该上Vector search了。
Abstract:
Abstract NPBS (Natural Products & Biological Sources) database is a chemical data resource with relational data between natural products and biological sources, manually curated from literatures of natural product researches. … >>>
Abstract NPBS (Natural Products & Biological Sources) database is a chemical data resource with relational data between natural products and biological sources, manually curated from literatures of natural product researches. The relational data link a specific species and all the natural products derived from it and contrarily link a specific natural product and all the biological sources. The biological sources cover diverse species of plant, bacterial, fungal and marine organisms; the natural molecules have proper chemical structure data and computable molecular properties and all the relational data have corresponding references. NPBS database provides a wider choice of biological sources and can be used for dereplication to prevent re-isolation and re-characterization of already known natural products. Database URL: http://www.organchem.csdb.cn/scdb/NPBS <<<
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