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1.
尹志
(2025-07-31 23:59):
#paper doi: 10.48550/arXiv.2507.06216 Unitary designs in nearly optimal depth. 文章设计了一种全新的量子电路,该电路可以接近理论最优深度高效构建unitray k-designs. 如果这个方案足够有效,那么对后续的量子算法的设计无疑非常有帮助。
arXiv,
2025-07-08T17:48:33Z.
DOI: 10.48550/arXiv.2507.06216
Abstract:
We construct $\varepsilon$-approximate unitary $k$-designs on $n$ qubits incircuit depth $O(\log k \log \log n k / \varepsilon)$. The depth isexponentially improved over all known results in all three parameters …
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We construct $\varepsilon$-approximate unitary $k$-designs on $n$ qubits incircuit depth $O(\log k \log \log n k / \varepsilon)$. The depth isexponentially improved over all known results in all three parameters $n$, $k$,$\varepsilon$. We further show that each dependence is optimal up toexponentially smaller factors. Our construction uses $\tilde{{O}}(nk)$ ancillaqubits and ${O}(nk)$ bits of randomness, which are also optimal up to $\log(nk)$ factors. An alternative construction achieves a smaller ancilla count$\tilde{{O}}(n)$ with circuit depth ${O}(k \log \log nk/\varepsilon)$. Toachieve these efficient unitary designs, we introduce a highly-structuredrandom unitary ensemble that leverages long-range two-qubit gates and low-depthimplementations of random classical hash functions. We also develop a newanalytical framework for bounding errors in quantum experiments involving manyqueries to random unitaries. As an illustration of this framework'sversatility, we provide a succinct alternative proof of the existence ofpseudorandom unitaries.
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2.
sqc
(2025-07-31 23:53):
#paper, 《A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy》, 10.1186/s13073-021-00987-8,
本研究开发了一个名为 Cancer Data Integrator(CanDI)的 Python 框架,用于整合来自 CCLE、DepMap、PICKLES、CORUM 等多源公开数据,实现跨组学(基因组、转录组、蛋白组、代谢组)与功能基因组数据的无缝查询与联合分析。作者通过统一索引与类对象抽象,使用户无需数据库背景即可快速完成复杂条件筛选与可视化。利用 CanDI,研究者在卵巢癌和乳腺癌模型中发现了 BRCA1 突变背景下 Fanconi Anemia 通路的合成致死性;在 KRAS 与 EGFR 突变 NSCLC 模型中评估了基因条件必需性;首次系统揭示了男性与女性 KRAS 突变结直肠癌、胰腺癌和肺癌模型中的性别差异必需基因;并整合外部支气管上皮 RNA-seq 数据,提名了 12 个定位于细胞膜、在 KRAS/EGFR 突变 NSCLC 中显著上调的潜在免疫治疗靶点。CanDI 以灵活、可扩展的方式降低了大规模癌症数据整合门槛,为发现新靶点、解释性别差异及设计联合治疗策略提供了高效工具。
Genome Medicine,
2021-12.
DOI: 10.1186/s13073-021-00987-8
Abstract:
AbstractBackgroundAdvances in cancer biology are increasingly dependent on integration of heterogeneous datasets. Large-scale efforts have systematically mapped many aspects of cancer cell biology; however, it remains challenging for individual scientists …
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AbstractBackgroundAdvances in cancer biology are increasingly dependent on integration of heterogeneous datasets. Large-scale efforts have systematically mapped many aspects of cancer cell biology; however, it remains challenging for individual scientists to effectively integrate and understand this data.ResultsWe have developed a new data retrieval and indexing framework that allows us to integrate publicly available data from different sources and to combine publicly available data with new or bespoke datasets. Our approach, which we have named the cancer data integrator (CanDI), is straightforward to implement, is well documented, and is continuously updated which should enable individual users to take full advantage of efforts to map cancer cell biology. We show that CanDI empowered testable hypotheses of new synthetic lethal gene pairs, genes associated with sex disparity, and immunotherapy targets in cancer.ConclusionsCanDI provides a flexible approach for large-scale data integration in cancer research enabling rapid generation of hypotheses. The CanDI data integrator is available athttps://github.com/GilbertLabUCSF/CanDI.
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3.
林海onrush
(2025-07-31 23:19):
#paper, 《Efficient Qudit Circuit for Quench Dynamics of 2+1D Quantum Link Electrodynamics》,10.48550/arXiv.2507.12589 ,
本研究提出了一种基于多能级量子比特(qudit)的高效量子电路框架,用于模拟2+1维U(1)格点规范电动力学的淬灭动力学。通过利用高斯定律积分出物质场,仅保留规范自由度,作者构建了无需辅助qubit的紧凑电路设计,并通过数值模拟验证其在现实噪声下仍能保持高度相干的动态演化表现。
该方法不仅大幅降低了量子资源消耗,还适用于任意自旋表示和更高维度格点系统,具备良好的可扩展性。相比传统qubit编码,qudit实现更贴近硬件特性,适用于当前和近期的量子处理器,为模拟高能物理非平衡现象提供了一条切实可行的量子计算路径。
arXiv,
2025-07-16T19:16:49Z.
DOI: 10.48550/arXiv.2507.12589
Abstract:
A major challenge in the burgeoning field of quantum simulation forhigh-energy physics is the realization of scalable $2+1$D lattice gaugetheories on state-of-the-art quantum hardware, which is an essential steptowards the …
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A major challenge in the burgeoning field of quantum simulation forhigh-energy physics is the realization of scalable $2+1$D lattice gaugetheories on state-of-the-art quantum hardware, which is an essential steptowards the overarching goal of probing $3+1$D quantum chromodynamics on aquantum computer. Despite great progress, current experimental implementationsof $2+1$D lattice gauge theories are mostly restricted to relatively smallsystem sizes and two-level representations of the gauge and electric fields.Here, we propose a resource-efficient method for quantum simulating $2+1$Dspin-$S$ $\mathrm{U}(1)$ quantum link lattice gauge theories with dynamicalmatter using qudit-based quantum processors. By integrating out the matterfields through Gauss's law, we reformulate the quantum link model in a purelyspin picture compatible with qudit encoding across arbitrary spatialdimensions, eliminating the need for ancillary qubits and reducing resourceoverhead. Focusing first on the spin-$1/2$ case, we construct explicit circuitsfor the full Hamiltonian and demonstrate through numerical simulations that thefirst-order Trotterized circuits accurately capture the quench dynamics even inthe presence of realistic noise levels. Additionally, we introduce a generalmethod for constructing coupling-term circuits for higher-spin representations$S>1/2$. Compared to conventional qubit encodings, our framework significantlyreduces the number of quantum resources and gate count. Our approachsignificantly enhances scalability and fidelity for probing nonequilibriumphenomena in higher-dimensional lattice gauge theories, and is readily amenableto implementation on state-of-the-art qudit platforms.
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4.
半面阳光
(2025-07-31 22:54):
#paper DOI: 10.1373/clinchem.2011.165910. Clinical Chemistry. 2011. Optimal Detection of Fetal Chromosomal Abnormalities by Massively Parallel DNA Sequencing of Cell-Free Fetal DNA from Maternal Blood.
这篇文章是基于低深度全基因组测序的NIPT技术在较为早期方法学建立阶段一篇技术方法学研究。文章采用了一种Normalized Chromosome Value(NCV)方法判定染色体非整倍体。为NGS-based NIPT的进一步流程化和商业化应用提供了统计建模和标准化流程的基础。目前illumina公司所持有的 VeriSeq NIPT Analysis Software的产品文档中引用了该文献,推测很可能是VeriSeq平台早期开发版本的相关文献。
Clinical Chemistry,
2011-7-1.
DOI: 10.1373/clinchem.2011.165910
Abstract:
BACKGROUND Massively parallel DNA sequencing of cell-free fetal DNA from maternal blood can detect fetal chromosomal abnormalities. Although existing algorithms focus on the detection of fetal trisomy 21 (T21), these …
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BACKGROUND Massively parallel DNA sequencing of cell-free fetal DNA from maternal blood can detect fetal chromosomal abnormalities. Although existing algorithms focus on the detection of fetal trisomy 21 (T21), these same algorithms have difficulty detecting trisomy 18 (T18). METHODS Blood samples were collected from 1014 patients at 13 US clinic locations before they underwent an invasive prenatal procedure. All samples were processed to plasma, and the DNA extracted from 119 samples underwent massively parallel DNA sequencing. Fifty-three sequenced samples came from women with an abnormal fetal karyotype. To minimize the intra- and interrun sequencing variation, we developed an optimized algorithm by using normalized chromosome values (NCVs) from the sequencing data on a training set of 71 samples with 26 abnormal karyotypes. The classification process was then evaluated on an independent test set of 48 samples with 27 abnormal karyotypes. RESULTS Mapped sites for chromosomes of interest in the sequencing data from the training set were normalized individually by calculating the ratio of the number of sites on the specified chromosome to the number of sites observed on an optimized normalizing chromosome (or chromosome set). Threshold values for trisomy or sex chromosome classification were then established for all chromosomes of interest, and a classification schema was defined. Sequencing of the independent test set led to 100% correct classification of T21 (13 of 13) and T18 (8 of 8) samples. Other chromosomal abnormalities were also identified. CONCLUSION Massively parallel sequencing is capable of detecting multiple fetal chromosomal abnormalities from maternal plasma when an optimized algorithm is used.
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5.
白鸟
(2025-07-31 22:41):
#paper Doi:10.1126/science.adz6423. Beyond the native repertoire (2025).
根据最近发表在science杂志上的3篇利用AI设计人工T细胞受体的文章,写的Perspective文章。AI在免疫治疗领域一个很有前瞻性的研究工作。
问题:癌症免疫疗法传统方法是从患者体内分离T细胞。T细胞进行改造,TCR受体能够识别癌细胞pMHC呈递的短肽,监测威胁并攻击癌细胞。但该技术的问题是天然存在的TCR通常对肿瘤抗原的亲和力不够理想。
研究目的:3篇文章利用AI设计高特异性 pMHC 结合“人工 TCR”,能更精确地靶向肿瘤抗原,有望加速癌症免疫疗法。基于大量蛋白质序列或结构数据集训练的生成式蛋白质模型,正在根本性地改变人工T细胞受体(TCR)的设计。
解决思路:
Householder等、Johansen等和Liu等研究团队均采用了同一套核心先进人工智能工具。
(1)AlphaFold2——可根据氨基酸序列预测蛋白质的三维结构——被用于预测目标pMHC结构;
(2)RoseTTAFold扩散模型——生成具有预测结构亲和力与选定pMHC结合的稳定蛋白单体(单聚肽支架)的多样化序列。
(3)基于深度学习的蛋白质序列设计方法——蛋白质消息传递神经网络(ProteinMPNN)——预测出多个可能的氨基酸序列,这些序列将生成选定的支架结构。
(4)随后再次调用AlphaFold2,预测每个支架设计与目标pMHC的结合方式,并基于iPAE指标进行排序。
(5)通过使用ProteinMPNN生成更多样化的序列,并随后通过酵母表面展示法进行pMHC结合实验验证,最后在T细胞中进行功能实验。
尽管三项研究的方案在基本方法和工具上具有可比性,但具体应用在细节和规模上存在差异。
Science,
2025-7-24.
DOI: 10.1126/science.adz6423
6.
徐炳祥
(2025-07-31 20:32):
#paper doi: 10.1038/nmeth.3329 Nature Methods, 2015, Identification of active transcriptional regulatory elements from GRORO-seq data。哺乳动物基因组上存在大量非编码的活跃的双向转录区域,这些区域往往发挥调控元件(如增强子)的作用,因而成为表观遗传研究的重要对象。GRO-seq/PRO-seq是测定这些转录调控元件(TRE)的最有效高通量手段。这篇旧文报道了一种称为dREG的有监督学习算法,可在GRO-seq数据中系统性检测TRE。预测是利用SVM模型学习GRO-seq在基因启动子位点处的信号特征进而外推至整个基因组实现的。通过与DNase-seq和多种组蛋白修饰位点的联合分析,本文将基因组上的顺式调控元件大致分为活跃转录的调控元件、开放但不转录的调控元件、有增强子特征但不开放的调控元件和绝缘子四个大类。通过每类中特征性的转录因子结合位点富集情况和eQTL/GWAS数据的富集验证了这些结果的可靠性。本文虽旧,但对理解顺式作用元件的组成与功能有重要参考意义。PRO-seq/GRO-seq虽然操作繁琐、对实验员技术和耐心要求很高,但也是探测新生转录本和活跃调控元件的金标准,值得额外关注。
7.
符毓
(2025-07-31 20:24):
#paper doi:10.23919/ICEMS.2018.8549105, 2018 21st International Conference on Electrical Machines and Systems (ICEMS), 2018, Challenges of the Hairpin Technology for Production Techniques. 扁线电机已经大量应用在汽车驱动电机上,本文介绍了扁线电机生产过程中的每个环节的难点和挑战。然而2018年文章提到的问题其实产业界都已经基本解决,所以在一些工业问题上,学术界未必领先于产业界。这是值得在后续论文学习中留意的问题
Abstract:
No abstract available.
8.
钟鸣
(2025-07-31 17:18):
#paper doi:10.1073/pnas.2426211122 A multifunctional anti-O-Antigen human monoclonal antibody protects against Shigella sonnei infection in vivo
这是篇发表在PNAS上的微生物学论文,核心成就是开发了一株针对志贺菌的人源单抗。作者通过流式直接从受控感染志贺菌的志愿者血液中分离到了3万多个B细胞,诱导分泌抗体后使用ELISA和L-SBA筛选到了2个具有体外杀菌活性的抗体,并进行定向改造:Hexa1突变增强效应功能;LS突变延长半衰期。作者从体内、体外、机制3个角度研究了该抗体的有效性,体内实验用了小鼠败血症模型、小鼠肺炎模型;体外实验使用了肠道芯片、实时活菌成像技术、细胞入侵实验;机制分析用了STD-NMR表位定位、活菌成像技术。本文的选题及成果现实性和实用性很强,也比较全面严谨。
Proceedings of the National Academy of Sciences,
2025-7-29.
DOI: 10.1073/pnas.2426211122
Abstract:
Shigellosis is a global public health challenge that mostly affects low- and middle-income countries and causes considerable morbidity and mortality among children under 5 y of age. Multi- and extensively …
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Shigellosis is a global public health challenge that mostly affects low- and middle-income countries and causes considerable morbidity and mortality among children under 5 y of age. Multi- and extensively drug-resistant Shigella sonnei strains associated with recent outbreaks in high-income countries exacerbate the problem and have prompted the World Health Organization to include Shigella spp. among the high-risk pathogens for which novel prophylactic and therapeutic tools are urgently needed. Among the most promising and cutting-edge solutions, monoclonal antibodies are gaining considerable attention in the infectious diseases field. Here, we report the discovery of human monoclonal antibodies against S. sonnei , a species whose prevalence is constantly increasing worldwide and is associated with frequent drug-resistant infections. We isolated antibodies generated in response to an experimental S. sonnei vaccine followed by a controlled human infection and screened them by using a panel of high-throughput assays. We identified a molecule which exhibited potent bactericidal activity in vitro, inhibition of invasion of epithelial cells and conferred full protection from S. sonnei infection in vivo. Overall, our study provides a candidate antibody that can rapidly progress to industrial development for application as a prophylactic, therapeutic, and diagnostic tool against shigellosis.
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9.
哪有情可长
(2025-07-28 14:14):
#paper Massive haplotypes underlie ecotypic differentiation in sunflowers,Nature,27 August 2020,doi.org/10.1038/s41586-020-2467-6。 该论文通过对1,506株野生向日葵(包括三个物种:Helianthus annuus、H. petiolaris 和 H. argophyllus)的重测序分析,发现了37个大型(1-100 Mbp)、非重组的单倍型区块(haploblocks)。这些单倍型区块与多个生态相关性状(如开花时间、种子大小)以及土壤和气候特征显著相关。主要发现包括:
1)单倍型区块的生态适应性作用:例如,在 H. argophyllus 中,一个约30 Mbp的单倍型区块(包含 HaFT1 基因)控制沿海与内陆种群之间77天的开花时间差异,且该区块可能是从 H. annuus 通过渐(introgression)引入的。
2)沙丘适应:在 H. petiolaris 中,多个单倍型区块与沙丘适应性相关,包括种子大小和土壤养分利用效率的差异。
3)结构变异的作用:大多数单倍型区块与大型结构变异(如倒位)相关,这些变异通过抑制重组维持适应性等位基因的组合。
10.
李翛然
(2025-07-28 13:44):
#paper doi:10.1126/science.adv9817,Science,Sarah Lewis https://orcid.org/0009-0009-6484-0352, et al. Scalable emulation of protein equilibrium ensembles with generative deep learning 蛋白质功能依赖其动态构象变化(如结构域运动、局部解折叠),但现有技术存在瓶颈:
静态模型局限:AlphaFold等仅预测单一结构,无法捕捉动态过程。
传统方法缺陷:实验技术(冷冻电镜、单分子实验)通量低;分子动力学(MD)模拟计算成本极高(毫秒级模拟需数月GPU时间)。
BioEmu的核心创新
微软团队提出BioEmu,一种基于生成式扩散模型的系统,实现高效、高精度蛋白质构象集合模拟:
架构设计:融合AlphaFold的evoformer编码器与扩散模型,输入蛋白质序列,通过30–50步去噪生成三维构象集合。
三阶段训练策略:
预训练:使用聚类后的AlphaFold数据库学习构象多样性;
微调:整合>200毫秒全原子MD数据(覆盖1100+CATH结构域),逼近热力学平衡分布;
精调:引入PPFT算法,利用50万实验稳定性数据(ΔG/ΔΔG)优化模型与实验一致性。
Science,
2025-7-10.
DOI: 10.1126/science.adv9817
Abstract:
Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that emulates protein equilibrium ensembles …
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Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep learning system that emulates protein equilibrium ensembles by generating thousands of statistically independent structures per hour on a single GPU. BioEmu integrates over 200 milliseconds of molecular dynamics (MD) simulations, static structures and experimental protein stabilities using novel training algorithms. It captures diverse functional motions—including cryptic pocket formation, local unfolding, and domain rearrangements—and predicts relative free energies with 1 kcal/mol accuracy compared to millisecond-scale MD and experimental data. BioEmu provides mechanistic insights by jointly modelling structural ensembles and thermodynamic properties. This approach amortizes the cost of MD and experimental data generation, demonstrating a scalable path toward understanding and designing protein function.
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11.
小年
(2025-07-27 22:43):
#paper doi:10.1101/2022.09.13.507640, Nature, David T.et al. The genomic basis of childhood T-lineage acute lymphoblastic leukaemia
研究团队对 1300 多例接受统一治疗的儿童 T 系急性淋巴细胞白血病(T-ALL)患者的肿瘤及缓解样本进行全基因组、转录组测序,并结合恶性和正常 T 细胞前体的表观基因组及单细胞分析,构建了包含 15 种亚型的 T-ALL 基因组特征图谱。发现 T-ALL 中存在广泛的非编码基因组改变,例如增强子失调通过多种机制导致癌基因表达异常,部分亚型中造血干细胞发育调节基因存在显著基因组改变。团队通过整合染色质拓扑分析,揭示了非编码区域在 T-ALL 发病中的关键作用,鉴定出 “ETP 样” 白血病这一具有多样免疫表型和独特基因组特征的亚型。基因组分析显示,多种遗传改变和疾病亚型是生存和治疗失败的独立预测因素,部分亚型呈现出与预后密切相关的特定基因表达模式。该研究建立了全面的儿童 T-ALL 基因组学数据库,揭示了非编码基因组调控异常和疾病亚型异质性的核心作用,提示基于基因组特征的亚型分类和风险分层可作为潜在治疗策略优化的依据。
12.
颜林林
(2025-07-26 13:41):
#paper doi:10.1038/s41586-025-09290-7, Nature, 2025, Structural variation in 1,019 diverse humans based on long-read sequencing. 这项工作相当于是“千人基因组项目的结构变异版”:基于千人基因组项目的1,019例代表性人群样本的中等深度长读长测序,构建了目前最全面的SV图谱之一。研究团队开发了SAGA分析框架,结合线性与图参考,系统地识别、分型并注释了超17万个SV位点,特别提升了插入、VNTR、多等位位点等此前难以准确解析的类型。文章从方法、数据到机制探索均具高完成度。其深入分析了SV在人群间的分布特征、形成机制(如NAHR、HDR、微同源介导修复等),以及移动元件转导事件的谱系和位点偏好,提供了关于SV发生、演化与功能影响的一系列重要观察。相比此前基于短读长的研究,本项目对稀有变异、多态性、反复事件等均有数量级上的提升。最终发布的pangenome资源,为今后的SV研究、图基因组方法开发和临床变异注释奠定了重要基础。整体现为“图基因组+长读长”模式在人群尺度研究中的一个范式转折点。对于SV感兴趣的,也可以深入研究和重复一下这篇文章中的方法。
Abstract:
Abstract Genomic structural variants (SVs) contribute substantially to genetic diversity and human diseases1–4, yet remain under-characterized in population-scale cohorts5. Here we conducted long-read sequencing6 in 1,019 humans to construct an …
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Abstract Genomic structural variants (SVs) contribute substantially to genetic diversity and human diseases1–4, yet remain under-characterized in population-scale cohorts5. Here we conducted long-read sequencing6 in 1,019 humans to construct an intermediate-coverage resource covering 26 populations from the 1000 Genomes Project. Integrating linear and graph genome-based analyses, we uncover over 100,000 sequence-resolved biallelic SVs and we genotype 300,000 multiallelic variable number of tandem repeats7, advancing SV characterization over short-read-based population-scale surveys3,4. We characterize deletions, duplications, insertions and inversions in distinct populations. Long interspersed nuclear element-1 (L1) and SINE-VNTR-Alu (SVA) retrotransposition activities mediate the transduction8,9 of unique sequence stretches in 5′ or 3′, depending on source mobile element class and locus. SV breakpoint analyses point to a spectrum of homology-mediated processes contributing to SV formation and recurrent deletion events. Our open-access resource underscores the value of long-read sequencing in advancing SV characterization and enables guiding variant prioritization in patient genomes.
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13.
DeDe宝
(2025-07-21 11:14):
#paper Do Spatial Navigation and Episodic Memory Rely on the Same Systems? Evidence From a Naturalistic Experience With Children and Adults. JEPG,2025.07, https://doi.org/10.1037/xge0001805本研究探讨自然情境下儿童与成人的空间导航与情景记忆是否共享同一套认知系统。实验令130名被试(8–13岁儿童88人与成人42人)参与一次8分钟真实导览,学习16个物品的物品外观(感知细节)、物品位置(空间布局)和发生的事件。随后完成空间任务(地图构建、路径效率、指向)和情景记忆任务(自由回忆与感知细节识别、事件细节识别、时空细节识别)。因子分析提取出两个高度相关但可区分的因子:“空间-时间结构”与“感知-事实-现场记忆”,表明系统交织而非独立。年龄提升整体表现,但因子结构跨龄一致。结论:在现实编码中,空间与情景记忆紧密整合,挑战传统分离模型。
14.
惊鸿
(2025-07-10 23:31):
#paper 《Coherent bunching of anyons and dissociation in an interference experiment》25 June 2025 doi:10.1038/s41586-025-09143-3
该研究通过精密的纳米器件设计与极低温量子输运测量,首次观测到分数量子霍尔态中任意子的相干“成团”与可控“解离”现象。实验中,团队利用砷化镓/铝镓砷(GaAs/AlGaAs)异质结材料构建手性马赫-曾德尔干涉仪,在15 mK超低温与强磁场(>10 T)下,发现填充因子ν=2/3、3/5、4/7时出现异常通量周期ΔΦ=νΦ₀(Φ₀为磁通量子),而非理论预期的(e/e*)Φ₀周期。这一反常现象源于多个基本准粒子自发聚集成相干“束团”,如四重态(ν=4/7)或三重态(ν=3/5),形成集体干涉行为。更关键的是,通过调节沉积在器件中心的金属栅极电压(Vₜ₉),研究者成功诱导局域准粒子态,使“束团”解离为单个准粒子,恢复常规通量周期,首次实现任意子集体行为的主动调控。
此项工作揭示了拓扑量子物态中未被理论预见的多体关联效应,挑战了现有分数量子霍尔理论框架。其技术突破在于将纳米尺度静电操控与量子相干测量结合,为设计具有动态拓扑保护能力的量子计算材料提供了新范式。实验揭示的“成团-解离”相变机制,暗示任意子可能通过集体态增强对环境噪声的鲁棒性,这对开发容错量子比特具有重要启示——若能操控此类相变,或可构建自适应拓扑保护的量子信息存储单元。
Nature,
2025-6-26.
DOI: 10.1038/s41586-025-09143-3
Abstract:
No abstract available.
15.
刘昊辰
(2025-07-09 14:59):
#paper Rapfi Distilling Efficient Neural Network for the Game of Gomoku. 本文提出 Rapfi,一种高效的五子棋智能体,在有限计算环境中表现优于基于 CNN 的智能体。Rapfi 利用从 CNN 提炼的基于模式的码本压缩神经网络,以及在输入变化较小时最小化计算的增量更新方案。这种新网络使用数量级更少的计算量,达到与 ResNet 等更大神经网络相似的精度。得益于增量更新方案,深度优先搜索方法(如 α-β 搜索)可以显著加速。通过精心调整评估和搜索,Rapfi 在缺乏 GPU 等加速器的有限计算资源下,实力超越了基于 AlphaZero 算法的最强开源五子棋 AI Katagomo。Rapfi 在 Botzone 的 520 个五子棋智能体中排名第一,并在 2024 年 GomoCup 中夺冠。下载地址:https://arxiv.org/pdf/2503.13178
arXiv,
2025-03-17T13:53:57Z.
DOI: 10.48550/arXiv.2503.13178
Abstract:
Games have played a pivotal role in advancing artificial intelligence, withAI agents using sophisticated techniques to compete. Despite the success ofneural network based game AIs, their performance often requires significantcomputational …
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Games have played a pivotal role in advancing artificial intelligence, withAI agents using sophisticated techniques to compete. Despite the success ofneural network based game AIs, their performance often requires significantcomputational resources. In this paper, we present Rapfi, an efficient Gomokuagent that outperforms CNN-based agents in limited computation environments.Rapfi leverages a compact neural network with a pattern-based codebookdistilled from CNNs, and an incremental update scheme that minimizescomputation when input changes are minor. This new network uses computationthat is orders of magnitude less to reach a similar accuracy of much largerneural networks such as Resnet. Thanks to our incremental update scheme,depth-first search methods such as the alpha-beta search can be significantlyaccelerated. With a carefully tuned evaluation and search, Rapfi reachedstrength surpassing Katagomo, the strongest open-source Gomoku AI based onAlphaZero's algorithm, under limited computational resources where acceleratorslike GPUs are absent. Rapfi ranked first among 520 Gomoku agents on Botzone andwon the championship in GomoCup 2024.
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16.
龙海晨
(2025-07-07 21:01):
#paper Saadh M. Epigallocatechin gallate (EGCG) combined with zinc sulfate inhibits Peste des petits ruminants virus entry and replication. Saudi J Biol Sci. 2021 Nov;28(11):6674-6678. doi: 10.1016/j.sjbs.2021.07.035. Epub 2021 Jul 17. PMID: 34764780; PMCID: PMC8568804.这是一篇研究小反刍兽疫病毒 ( Peste des petits ruminants virus , PPRV)的文章,表没食子儿茶素没食子酸酯(英文名Epigallocatechin gallate,简称EGCG)研究表明,EGCG与硫酸锌结合,可以显著抑制PPRV进入Vero细胞。这种组合可能够通过阻碍病毒适应来降低感染抗性。
Saudi Journal of Biological Sciences,
2021-11.
DOI: 10.1016/j.sjbs.2021.07.035
Abstract:
No abstract available.
17.
哪有情可长
(2025-07-07 20:10):
#paper Bypassing Negative Epistasis on Yield in Tomato Imposed by a Domestication Gene, Cell, 1 June 2017,https://doi.org/10.1016/j.cell.2017.04.032. 花序结构是决定作物产量的关键因素,但在番茄中,花序结构(如分枝程度)的改良受到限制,尤其是在大果型品种中,过度的分枝会导致花败育和低产。作者发现驯化基因(ej2w)和现代育种基因(j2)的相互作用会导致番茄产生过度的分枝和不育,因为这种负上位效应阻碍了番茄育种的进展。本论文通过对4193分野生和栽培的番茄进行种质筛选,发现了一个s2的突变体,其花序分枝且花梗无关节(jointless pedicel)。通过测序和遗传定位,鉴定出s2是由两个MADS-box转录因子基因(J2和EJ2)的突变引起的。首先使用CRISPR/Cas9技术创建了J2和EJ2的突变体(如j2CR和ej2CR),验证了它们的功能。后续通过酵母双杂交实验和转录组分析,揭示了J2和EJ2在花序分生组织成熟中的冗余作用。对其进行驯化和育种历史分析发现发现ej2w等位基因在番茄驯化过程中被选择(可能与果实增大相关),而j2等位基因在现代育种中被用于无关节性状,但两者结合会导致负上位效应。通过组合自然突变和基因编辑产生的等位基因(如弱等位基因ej2w和强等位基因ej2CR),创建了一系列花序复杂度的连续变异,并培育出弱分枝的高产杂交种。这是一个很好的利用基因编辑和自然等位基因的剂量效应,实现了花序结构的精准调控,并且将基础研究发现直接能够应用于育种,完整的展示了从基因到田间应用的完整的研究方案。
18.
少颖-focus reverse aging
(2025-07-05 05:54):
#paper doi: https://doi.org/10.1101/2025.06.11.659105
标题:X-Atlas/Orion: Genome-wide Perturb-seq Datasets via a Scalable Fix-Cryopreserve Platform for Training Dose-Dependent Biological Foundation Models
发表年份:2025年
总结:目前虚拟细胞的技术因为数据集的发表得到了比较大的提升,解决了大约40-50%的核心数据问题。X-Atlas/Orion 数据集的构建大约18-25人参与,其中有斯坦福大学教授的学生和谷歌公司的高管, 也有参与过药物研发整个流程的人,开发这个数据集的公司里面大佬云集,有斯坦福大学前教授,也有诺奖获得者,也有强生公司前CEO,阵容堪称世界顶尖。感悟:虚拟细胞的设计是顶尖科学家做的事情,所以这件事情会让人很有成就感。我可以参与,但是需要做好投入大量时间的准备。
公众号文章有更详细解读和分析:https://mp.weixin.qq.com/s/evVxdkRds8ZCbXVgnlmWAg
bioRxiv,
2025-6-16.
DOI: 10.1101/2025.06.11.659105
Abstract:
AbstractThe rapid expansion of massively parallel sequencing technologies has enabled the development of foundation models to uncover novel biological findings. While these have the potential to significantly accelerate scientific discoveries …
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AbstractThe rapid expansion of massively parallel sequencing technologies has enabled the development of foundation models to uncover novel biological findings. While these have the potential to significantly accelerate scientific discoveries by creating AI-driven virtual cell models, their progress has been greatly limited by the lack of large-scale high-quality perturbation data, which remains constrained due to scalability bottlenecks and assay variability. Here, we introduce “Fix-Cryopreserve-ScRNAseq” (FiCS) Perturb-seq, an industrialized platform for scalable Perturb-seq data generation. We demonstrate that FiCS Perturb-seq exhibits high sensitivity and low batch effects, effectively capturing perturbation-induced transcriptomic changes and recapitulating known biological pathways and protein complexes. In addition, we release X-Atlas: Orion edition (X-Atlas/Orion), the largest publicly available Perturb-seq atlas. This atlas, generated from two genome-wide FiCS Perturb-seq experiments targeting all human protein-coding genes, comprises eight million cells deeply sequenced to over 16,000 unique molecular identifiers (UMIs) per cell. Furthermore, we show that single guide RNA (sgRNA) abundance can serve as a proxy for gene knockdown (KD) efficacy. Leveraging the deep sequencing and substantial cell numbers per perturbation, we also show that stratification by sgRNA expression can reveal dose-dependent genetic effects. Taken together, we demonstrate that FiCS Perturb-seq is an efficient and scalable platform for high-throughput Perturb-seq screens. Through the release of X-Atlas/Orion, we highlight the potential of FiCS Perturb-seq to address current scalability and variability challenges in data generation, advance foundation model development that incorporates gene-dosage effects, and accelerate biological discoveries.
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19.
孤舟蓑笠翁
(2025-07-01 22:26):
#paper 【doi】10.1016/j.phymed.2025.156828;【发表年份】2025年;【期刊】Phytomedicine;【标题】Deciphering the molecular mechanisms of QLQX capsules in heart failure: A multi-omics perspective。【内容总结】这篇论文研究了中药QLQX胶囊对保留射血分数心衰(HFpEF)的治疗机制,简单说就是想搞清楚这个药为啥能改善心脏功能。研究者先用网络药理学预测了QLQX的活性成分和潜在靶点,然后通过大鼠实验(包括超声心动图、RNA测序、蛋白质组学和代谢组学)验证效果,发现QLQX能通过调节cGMP-PKG信号通路等改善心脏舒张功能。具体来说,他们先通过计算机分析找到QLQX的44种活性成分可能作用于530个靶点,其中38个与HFpEF相关;接着用手术+高盐饮食制造HFpEF大鼠模型,给不同剂量QLQX治疗8周后,用多组学方法发现药物显著提升了血清一氧化氮(NO)和环磷酸鸟苷(cGMP)水平,改善了心肌肥厚指标,并通过转录组发现216个基因表达被逆转,蛋白质组显示401个差异蛋白被调控,代谢组显示QLQX能纠正脂代谢异常。最终证明QLQX像"多面手"一样通过cGMP-PKG通路协调改善血管功能、钙离子平衡和能量代谢,这解释了它对复杂病因的HFpEF的疗效。
20.
ZĒNG Yíngzhū (Zoo) 曾莹珠
(2025-06-30 23:51):
#paper
DOI: 10.1093/schbul/sbaf072
Schizophrenia Bulletin
2025
Candidate Targets for Resilience Training to Reduce Transdiagnostic Risk for Mental Illness.
韧性训练(RT)作为基于正念的4次团体干预,显著降低抑郁、焦虑和压力感知。RT降低情绪反应性的机制,可能适用于PTSD的早期干预。未来可以在创伤暴露被试中测试RT,评估对PTSD症状的预防效果。
Schizophrenia Bulletin,
2025-6-17.
DOI: 10.1093/schbul/sbaf072
Abstract:
Abstract Background and Hypothesis Stress sensitivity may represent an important target for resilience-promoting, preventive interventions. Resilience Training (RT) is a 4-session, group-based behavioral intervention, focusing on mindfulness-based skills, that leads …
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Abstract Background and Hypothesis Stress sensitivity may represent an important target for resilience-promoting, preventive interventions. Resilience Training (RT) is a 4-session, group-based behavioral intervention, focusing on mindfulness-based skills, that leads to reductions in psychopathology. To investigate the mechanisms of RT, the current study tested whether acquiring the skills taught in RT leads to decreases in psychopathology via reductions in one manifestation of stress sensitivity, emotion reactivity, and associated changes in hippocampal-frontal connectivity. Study Design An open trial of RT was conducted in 103 non-help-seeking young adults with mild-to-moderate psychotic experiences (PEs) and/or symptoms of depression. Transdiagnostic symptoms, emotion reactivity, and mindfulness-related skills were measured, and, in a subset of participants (n = 41), resting-state, functional magnetic resonance imaging (fMRI) data were collected, before and after completion of RT. Study Results Replicating and extending findings of prior studies of RT, significant increases in mindfulness-related RT skills and significant decreases in transdiagnostic symptoms and emotion reactivity, as well as changes in hippocampal-frontal functional connectivity, were observed following RT (all P < .02). Mediation analyses revealed that associations between the acquisition of the RT skills and decreases in symptoms (P < .006) were fully mediated by the decrease in emotion reactivity, which was also correlated with a significant pre-to-post increase in hippocampal-dorsolateral prefrontal cortex connectivity (P = .032). Conclusions RT may lead to improvements in mental health by increasing the capacity to manage day-to-day stress. Future randomized controlled trials with extended follow-up can determine whether such improvements decrease the likelihood of developing disabling mental illnesses in transdiagnostically at-risk individuals.
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