来自杂志 Scientific Reports 的文献。
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1.
半面阳光
(2024-12-31 22:15):
#paper DOI: https://doi.org/10.1038/s41598-017-02031-5. Sci Rep 2017, Novel Algorithms for Improved Sensitivity in Non-Invasive Prenatal Testing. 这篇文章介绍了作者团队开发的旨在提升NIPT检测灵敏性和特异性的三种算法，分别是 the chi-squared-based variation reduction (χ2VR)、the regression-based Z-score (RBZ)、the Match QC score。其中The χ2VR算法用于减少样本之间每条染色体所比对上的reads数的差异，RBZ算法用于染色体三体的预测，Match QC score用于反应对照组对特定的样本是否具有代表性。此外，还将这些算法与NIPT检测中常用的算法的检测效果进行了比较。结果显示χ2VR 和 RBZ 都对减少变异性有帮助，进而提升NIPT检测灵敏性。该研究还发现一个最有的算法组合是在分析的预处理过程中使用常用的GC correction方法 和 χ2VR方法，在染色体三体预测流程中使用RBZ方法。
Scientific Reports,
2017-5-12.
DOI: 10.1038/s41598-017-02031-5
Abstract:
AbstractNon-invasive prenatal testing (NIPT) of cell-free DNA in maternal plasma, which is a mixture of maternal DNA and a low percentage of fetal DNA, can detect fetal aneuploidies using massively …
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AbstractNon-invasive prenatal testing (NIPT) of cell-free DNA in maternal plasma, which is a mixture of maternal DNA and a low percentage of fetal DNA, can detect fetal aneuploidies using massively parallel sequencing. Because of the low percentage of fetal DNA, methods with high sensitivity and precision are required. However, sequencing variation lowers sensitivity and hampers detection of trisomy samples. Therefore, we have developed three algorithms to improve sensitivity and specificity: the chi-squared-based variation reduction (χ2VR), the regression-based Z-score (RBZ) and the Match QC score. The χ2VR reduces variability in sequence read counts per chromosome between samples, the RBZ allows for more precise trisomy prediction, and the Match QC score shows if the control group used is representative for a specific sample. We compared the performance of χ2VR to that of existing variation reduction algorithms (peak and GC correction) and that of RBZ to trisomy prediction algorithms (standard Z-score, normalized chromosome value and median-absolute-deviation-based Z-score). χ2VR and the RBZ both reduce variability more than existing methods, and thereby increase the sensitivity of the NIPT analysis. We found the optimal combination of algorithms was to use both GC correction and χ2VR for pre-processing and to use RBZ as the trisomy prediction method.
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2.
符毓 Yu
(2024-08-31 23:18):
#paper doi: 10.1038/s41598-022-06214-7, Science Report, 2022, Low voltage optical fiber positioner robot based on minimum inductance hollow cup motors
新一代光纤定位机器人选用了相位电感最小的4 mm空心杯电机。由于光纤定位机器人负载为恒定值，电机转动惯量很小，因此提出了一种基于空间矢量脉冲宽度调制的开环定位控制方法，并通过相关实验策略直接整定具体的开环参数。从细分、基频、造波方式、峰值电流4个方面详细讨论了开环驱动方式的关键因素。基于实际光纤定位机器人，搭建了硬件驱动与考核平台。定位试验表明，所提方法实用有效，满足新一代光纤定位机器人的精密定位需求。
Scientific Reports,
2022-2-17.
DOI: 10.1038/s41598-022-06214-7
Abstract:
AbstractWith the further transformation of The Large Sky Area Multi-Object Fiber Spectroscopic Telescope, the new generation of fiber positioner robot chooses a 4 mm hollow cup motor with minimum phase …
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AbstractWith the further transformation of The Large Sky Area Multi-Object Fiber Spectroscopic Telescope, the new generation of fiber positioner robot chooses a 4 mm hollow cup motor with minimum phase inductance. Because the load of the fiber positioner robot is constant and the inertia of the motor is very small, an open loop positioning control method based on Space Vector Pulse Width Modulation is proposed, and the specific open loop parameters are directly tuned by relevant experimental strategies. The critical factors of the open loop driving mode are discussed in detail from four aspects: subdivision, fundamental frequency, wave generation mode and peak current. Based on the actual fiber positioner robot, the hardware driver and assessment platform are built. The positioning tests show that the method proposed is practical and effective, and meets the precision positioning demand of the new generation optical fiber positioner robot.
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