孤舟蓑笠翁 (2025-08-29 16:07):
paper 【doi】10.1016/j.cell.2025.07.042；【发表年份】2025年；【期刊】Cell；【标题】Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers。【内容总结】这篇研究想找出能预测晚期前列腺癌患者对不同治疗（如激素疗法和化疗）反应的生物标志物，通过分析1523名患者的肿瘤RNA表达数据（使用微阵列技术检测基因表达水平），结合长期生存随访数据，发现高Decipher评分（反映肿瘤增殖活性）和PTEN失活（通过PTEN_loss_Liu转录组特征判断）的肿瘤对化疗药物多西他赛更敏感，而雄激素受体（AR）信号强的肿瘤生存期更长。主要方法包括：临床级微阵列检测肿瘤转录组、免疫组化验证（Ki-67和PTEN蛋白）、多变量Cox比例风险模型分析生存关联、预定义的生物标志物-治疗交互作用检验。结果显示Decipher评分高的转移性患者接受多西他赛后死亡风险降低36%（HR=0.64），PTEN失活肿瘤的死亡风险降低43%（HR=0.57），而AR信号活跃与更好预后相关（非转移患者HR=0.58）。
Cell, 2025-8. DOI: 10.1016/j.cell.2025.07.042
Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers
Emily Grist, Peter Dutey-Magni, Marina A. Parry, Larissa Mendes, Ashwin Sachdeva, James A. Proudfoot, Anis A. Hamid, Mazlina Ismail, Sarah Howlett, Stefanie Friedrich, ... >>>
Emily Grist, Peter Dutey-Magni, Marina A. Parry, Larissa Mendes, Ashwin Sachdeva, James A. Proudfoot, Anis A. Hamid, Mazlina Ismail, Sarah Howlett, Stefanie Friedrich, Lia DePaula Oliveira, Laura Murphy, Christopher Brawley, Oluwademilade Dairo, Sharanpreet Lall, Yang Liu, Daniel Wetterskog, Anna Wingate, Karolina Nowakowska, Leila Zakka, Claire L. Amos, Nafisah B. Atako, Victoria Wang, Hannah L. Rush, Robert J. Jones, Hing Leung, William R. Cross, Silke Gillessen, Chris C. Parker, Teresa Marafioti, Alfonso Urbanucci, Matthew Fittall, Edward M. Schaeffer, Daniel E. Spratt, David Waugh, Thomas Powles, Matthew R. Sydes, Felix Y. Feng, Daniel M. Berney, Mahesh K.B. Parmar, Noel W. Clarke, Elai Davicioni, Tamara L. Lotan, Christopher J. Sweeney, Louise C. Brown, Nicholas D. James, Gerhardt Attard <<<
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