孤舟蓑笠翁 (2025-06-26 19:41):
#paper 【doi】10.1016/j.cell.2025.06.001；【发表年份】2025年；【期刊】Cell；【标题】Systematic profiling reveals betaine as an exercise mimetic for geroprotection。【内容总结】这篇论文想搞清楚运动为什么能抗衰老，他们找了13个年轻男性做实验，先测了静息状态的数据，然后让他们做急性运动（单次5公里跑）和长期运动（25天隔天跑），用单细胞测序、代谢组学等方法分析了血液和粪便样本。简单说发现长期运动后肾脏产生的甜菜碱（betaine）变多了，这种物质能抑制TBK1蛋白，减少炎症和细胞衰老。详细来说，团队通过多组学分析发现长期运动改变了免疫细胞组成（增加初始淋巴细胞）、优化了代谢（增强脂肪酸利用），特别重要的是肾脏中甜菜碱代谢通路被激活。体外实验证明甜菜碱直接结合并抑制促炎蛋白TBK1，老年小鼠喝含甜菜碱的水后，肌肉功能、认知能力都变好，多个器官的衰老指标改善。主要方法包括：人体运动干预实验、单细胞RNA测序（10x Genomics）、质谱代谢组学（LC-MS/MS）、免疫荧光染色、小鼠行为学测试等。
Cell, 2025-6. DOI: 10.1016/j.cell.2025.06.001
Systematic profiling reveals betaine as an exercise mimetic for geroprotection
Lingling Geng, Jiale Ping, Ruochen Wu, Haoteng Yan, Hui Zhang, Yuan Zhuang, Taixin Ning, Jun Wang, Chuqian Liang, Jiachen Zhang, ... >>>
Lingling Geng, Jiale Ping, Ruochen Wu, Haoteng Yan, Hui Zhang, Yuan Zhuang, Taixin Ning, Jun Wang, Chuqian Liang, Jiachen Zhang, Qingqing Chu, Jing Zhang, Yifan Wen, Yaobin Jing, Shuhui Sun, Qin Qiao, Qian Zhao, Qianzhao Ji, Shuai Ma, Yusheng Cai, Yandong Zheng, Zhiran Zou, Zhiqing Diao, Mingheng Li, Hao Zhang, Jianli Hu, Liangzheng Fu, Wang Kang, Ruijun Bai, Hongkai Zhao, Sheng Zhang, Yingjie Ding, Jinghui Lei, Wei Wang, Yun Ji, Bo Gou, Guoqiang Sun, Jian Yin, Pengze Yan, Hao Li, Zehua Wang, Shikun Ma, Zunpeng Liu, Hezhen Shan, Qiaoran Wang, Tianling Cao, Shanshan Yang, Cui Wang, Ping Yang, Yanling Fan, Yanxia Ye, Jinghao Hu, Mengmeng Jiang, Ye Wang, Kan Liu, Yujing Li, Yuanxiang Li, Jingyi Li, Weimin Ci, Zi-Bing Jin, Xiaobing Fu, Xu Zhang, Guoguang Zhao, Juan Carlos Izpisua Belmonte, Si Wang, Moshi Song, Weiqi Zhang, Jing Qu, Guang-Hui Liu <<<
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