孤舟蓑笠翁 (2025-06-19 21:20):
#paper 【doi】10.1016/j.cell.2025.05.035；【发表年份】2025年；【期刊】Cell；【标题】Digital reconstruction of full embryos during early mouse organogenesis。【内容总结】这篇研究旨在构建小鼠胚胎早期器官发生的单细胞分辨率3D图谱，通过结合Stereo-seq空间转录组技术和细胞分割方法，对E7.5-E8.0阶段的6个小鼠胚胎进行高通量分析（获得104,343个细胞），开发了SEU-3D可视化平台实现3D“数字胚胎”重建；研究发现胚胎-胚外交界处存在“原基决定区（PDZ）”，该区域通过协调跨胚层信号（如BMP、Wnt）驱动心脏原基形成，同时绘制了中胚层（如心脏祖细胞空间亚群）和内胚层（如原肠管发育轨迹）的细胞图谱，揭示了器官发生早期的空间信号网络机制。
Cell, 2025-6. DOI: 10.1016/j.cell.2025.05.035
Digital reconstruction of full embryos during early mouse organogenesis
Peng Xie, Juan Shen, Yi Yang, Xinrui Wang, Wei Liu, Hailong Cao, Yanying Zheng, Chen Wu, Guangyao Mao, Linjin Chen, ... >>>
Peng Xie, Juan Shen, Yi Yang, Xinrui Wang, Wei Liu, Hailong Cao, Yanying Zheng, Chen Wu, Guangyao Mao, Linjin Chen, Jingjing He, Weiheng Zheng, Zepu Yang, Xiao Zhang, Xu Jiang, Xianfa Yang, Ke Fang, Zhao Zhang, Xin Xue, Xueting Chen, Chaoyi Wang, Xing Liu, Ling Liu, Xuebiao Yao, Naihe Jing, Wei Xie, Jin Liu, Hua Cao, Zhuojuan Luo, Xiaodong Fang, Chengqi Lin <<<
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