DeDe宝
(2025-06-01 17:15):
#paper https://doi.org/10.1101/2024.07.02.601741 bioRxiv.2025. 3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking
这篇文献研究了在自然摄食和饮水行为中,口腔面部感觉运动皮层(OSMCx)对舌头三维方向的编码特性,以及口腔触觉感觉丧失对这些编码特性的影响。实验对象为两只成年雄性恒河猴,实验任务分为摄食任务和饮水任务,目标脑区是OSMCx(OSMCx是大脑皮层中负责口腔面部感觉和运动功能的区域,包括初级运动皮层(MIo)、初级体感皮层(SIo)和皮层咀嚼区(CMA))。为了研究感觉反馈在控制舌头运动中的作用,研究者使用局部注射布比卡因(Bupivacaine HCL)和肾上腺素(Epinephrine)混合液,阻断三叉神经的感觉分支,以消除口腔触觉感觉。研究者在猴子的颅骨、下颌骨和舌头上植入直径为1毫米的钽珠,用于标记,并使用双平面视频放射照相术(biplanar videoradiography)以200 Hz的频率记录标记物的三维位置数据。同时,通过慢性植入的微电极阵列记录OSMCx中初级运动皮层(MIo)和初级体感皮层(SIo)的神经元放电活动。
实验结果表明,在摄食和饮水任务中,大多数MIo和SIo神经元表现出对三维舌运动方向的调谐,其中MIo神经元的方向调谐更为显著(尤其是在摄食任务中)。感觉神经阻断后,MIo和SIo中方向调谐的神经元比例显著下降,表明触觉反馈在控制舌运动方向中起着关键作用。。
bioRxiv,
2025-4-24.
DOI: 10.1101/2024.07.02.601741
3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking
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Abstract:
AbstractDirectional tongue movements are crucial for feeding and speech, ensuring proper food positioning for chewing and swallowing, as well as accurate sound production. While directional tuning in the arm region of the sensorimotor cortex during reaching tasks is well-studied, little is known about how 3D tongue direction is encoded in the orofacial sensorimotor cortex (OSMCx) during natural behaviors. Understanding this neural representation has important implications for rehabilitating individuals with orolingual dysfunctions. This study examines the directional tuning and population dynamics in OSMCx during naturalistic feeding and drinking, and how these are affected by sensory loss. Using biplanar videoradiography, we tracked implanted tongue markers in behaving rhesus macaques (Macaca mulatta) and simultaneously recorded 3D positional data with spiking activity from chronically implanted microelectrode arrays in primary motor (MIo) and somatosensory (SIo) areas of the orofacial cortex. In some sessions, tasks were preceded by bilateral nerve block injections to the sensory branches of the trigeminal nerve. Modulation to 3D tongue direction during feeding and drinking was found in most MIo and SIo neurons. Directional information in both individual- and population-level was higher in feeding and was more robust in MIo. Following sensory loss, alterations in tongue kinematics were accompanied by changes in directional information in MIo and SIo, manifesting as modifications in both individual neuron tuning characteristics and the broader dynamics of population-level neural activity. Overall, this study advances our understanding of how OSMCx contributes to complex, coordinated control of naturalistic tongue movements. It expands our current knowledge of orofacial control to three dimensions and demonstrates the specificity and adaptability of population activity in MIo and SIo in response to different behavioral contexts.
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