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他者 (2023-11-26 20:27):
#paper doi:10.1093/braincomms/fcac303. Implicit sensorimotor adaptation is preserved in Parkinson’s disease. 帕金森病是一种主要影响基底神经节回路的神经退行性疾病,被认为会损害获得和适应熟练运动的能力。帕金森病是否影响内隐运动适应仍然是一个有争议的研究领域:虽然多项研究显示帕金森人群的表现受损,但也有一些研究显示表现完好。这些差异可能是之前的研究混淆了隐性适应(implicit adaptation)和重新瞄准(strategic re-aiming)。这篇研究重点关注内隐运动适应中的视觉运动适应。视觉运动适应通过自动调整感觉运动来响应预期和实际感觉反馈之间的误差,从而使运动系统保持精确校准。本研究在视觉运动适应任务中匹配了对照,从而分离隐性适应和重新瞄准。结果发现帕金森病被试对视觉扰动的适应能力和对照被试相似,说明帕金森病不损害视觉运动适应。该发现为基底神经节在感觉运动学习中的作用提供了新的视角。
Abstract:
Our ability to enact successful goal-directed actions involves multiple learning processes. Among these processes, implicit motor adaptation ensures that the sensorimotor system remains finely tuned in response to changes in … >>>
Our ability to enact successful goal-directed actions involves multiple learning processes. Among these processes, implicit motor adaptation ensures that the sensorimotor system remains finely tuned in response to changes in the body and environment. Whether Parkinson's disease impacts implicit motor adaptation remains a contentious area of research: whereas multiple reports show impaired performance in this population, many others show intact performance. While there is a range of methodological differences across studies, one critical issue is that performance in many of the studies may reflect a combination of implicit adaptation and strategic re-aiming. Here, we revisited this controversy using a visuomotor task designed to isolate implicit adaptation. In two experiments, we found that adaptation in response to a wide range of visual perturbations was similar in Parkinson's disease and matched control participants. Moreover, in a meta-analysis of previously published and unpublished work, we found that the mean effect size contrasting Parkinson's disease and controls across 16 experiments involving over 200 participants was not significant. Together, these analyses indicate that implicit adaptation is preserved in Parkinson's disease, offering a fresh perspective on the role of the basal ganglia in sensorimotor learning. <<<
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