徐炳祥 (2023-07-26 17:11):
#paper doi: 10.1016/j.tem.2011.10.001. Trends in Endocrinology and Metabolism, 2012, Transcriptional networks and chromatin remodeling controlling adipogenesis。脂肪生成过程受一系列转录因子和表观遗传信号的控制,从而在时间上形成多波次的级联调控关系。此过程不仅是代谢研究的核心,也是表观遗传研究的重要载体。这篇旧文对脂肪生成过程中重要的转录因子的行为和调控关系,及其与其他表观信号的关系进行了梳理,并按照脂肪分化过程早期和晚期分别进行了系统性介绍。受限于时代,文中未涉及染色质空间构象和启动子-增强子相互作用的内容,但其主要观点至今仍有重要的参考价值。
Transcriptional networks and chromatin remodeling controlling adipogenesis
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Abstract:
Adipocyte differentiation is tightly controlled by a transcriptional cascade, which directs the extensive reprogramming of gene expression required to convert fibroblast-like precursor cells into mature lipid-laden adipocytes. Recent global analyses of transcription factor binding and chromatin remodeling have revealed 'snapshots' of this cascade and the chromatin landscape at specific time-points of differentiation. These studies demonstrate that multiple adipogenic transcription factors co-occupy hotspots characterized by an open chromatin structure and specific epigenetic modifications. Such transcription factor hotspots are likely to represent key signaling nodes which integrate multiple adipogenic signals at specific chromatin sites, thereby facilitating coordinated action on gene expression.
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