DeDe宝
(2026-04-02 02:27):
#paper Integration of Memory and Sensory Information in Skilled Sequence Production. The Journal of Neuroscience.2026
本研究聚焦序列动作中记忆与感觉信息的动态整合机制。当人类完成一系列动作时,需要整合之前的经验(内部记忆)和当前的刺激(外部感觉信息),但此前的研究孤立探讨这两个重要因素。本研究采用离散序列产生任务(Discrete Sequence Production Task, DSP)范式探究上述两个因素的影响,要求被试用右手五指重复固定长度的离散按键序列。研究操纵线索数量(外部感觉信息)和序列重复性(内部记忆),并构建证据累积计算模型拟合行为数据。研究发现:学习初期被试整合记忆与感觉线索;熟练且完全可预测时转为纯记忆驱动;引入违背引发不确定性后,重新整合两类信息。模型证实序列动作可并行独立计划接下来三次动作,且序列记忆遇冲突快速失活、需连续一致线索才缓慢重激活。该研究揭示了大脑灵活整合内外信息以生成精准序列动作的核心规律。
The Journal of Neuroscience,
2026-4-1.
DOI: 10.1523/JNEUROSCI.1797-25.2026
Integration of Memory and Sensory Information in Skilled Sequence Production
Amin Nazerzadeh,
Medha Porwal,
J. Andrew Pruszynski,
Jörn Diedrichsen
Abstract:
<br> Sequential movements rely on two information sources: external sensory cues and internal memory representations. Although often both sources jointly drive sequential behavior, previous research has primarily examined them in isolation. To address this, we trained participants (<br> <i>n</i><br> = 26, 15F) to perform sequences of rapid finger presses in response to numerical cues. Sensory influence was measured by varying the number of visible cues, and memory influence was determined by comparing repeating and random sequences. Early in learning, participants integrated sensory and memory information: repeating sequences were performed more quickly when more cues were visible. After learning, when repeating sequences were predictable with certainty, participants relied solely on memory and ignored sensory cues. However, when this certainty was manipulated by introducing occasional violations within repeating sequences, participants reverted to integrating memory with sensory cues. We propose a computational model that successfully predicted both speed and accuracy of individual presses. Critically, this model relied on the assumption that multiple movements are planned independently of each other. This independence assumption was then validated by examining response patterns to isolated violations in repeating sequences. Finally, we provide evidence into how sequence memories can be flexibly deactivated and reactivated in response to these violations. Together, these results reveal how brain dynamically integrates sensory and memory information to produce sequences of movements.<br>
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