徐炳祥 (2023-12-30 09:37):
#paper doi: 10.1186/s13073-020-00810-w Genome Medicine, 2023, DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies。成人中DNA甲基化图谱与肥胖间存在关联这一事实已为人们所知,然而此关联性是否在少儿期存在,二者间是否存在因果关系尚不明确。本文作为一项Meta分析,检查了来自全球23项研究的超过1万名儿童青少年参与者,分析了其血液DNA甲基化图谱和体重指数(BMI)的关系。通过横断面研究识别了在儿童青少年时期与BMI有显著关联的DNA甲基化位点,通过纵向研究探讨了其因果性。结果发现,仅少量血液DNA甲基化位点与BMI显著关联,且有证据显示其可能为高BMI的结果。本研究是一项典型的分子流行病学研究,其结构和方法有很多可取之处。
DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
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Abstract:
AbstractBackgroundDNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits.MethodsWe examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment.ResultsDNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance,P < 1.06 × 10−7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birthPenrichment = 1; childhoodPenrichment = 2.00 × 10−4; adolescencePenrichment = 2.10 × 10−7).ConclusionsThere were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity.
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