来自杂志 Trends in immunology 的文献。
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LXJ
(2022-12-31 11:55):
#paper doi: 10.1016/j.it.2022.10.005. Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment. Trends Immunol. 2022 Dec;43(12):969-977. 这是一篇综述研究，乳酸的产生被认为是恶性细胞逃避免疫监视的一种机制。最近的质谱技术进步和使用具有生理营养成分的细胞培养基，为乳酸及其共轭乳酸在肿瘤微环境中的作用提供了新的视角。本文作者回顾了鉴定乳酸作为哺乳动物肿瘤和免疫细胞的生理碳源的新工作，强调了其作为底物的用途不同于乳酸质子对细胞外环境的免疫抑制酸化的证据。总之，数据表明，应在维持细胞毒性CD8+T细胞生理乳酸代谢的同时，中和肿瘤内酸性的影响，以提高抗肿瘤免疫力。
Abstract:
Lactic acid production has been regarded as a mechanism by which malignant cells escape immunosurveillance. Recent technological advances in mass spectrometry and the use of cell culture media with a …
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Lactic acid production has been regarded as a mechanism by which malignant cells escape immunosurveillance. Recent technological advances in mass spectrometry and the use of cell culture media with a physiological nutrient composition have shed new light on the role of lactic acid and its conjugate lactate in the tumor microenvironment. Here, we review novel work identifying lactate as a physiological carbon source for mammalian tumors and immune cells. We highlight evidence that its use as a substrate is distinct from the immunosuppressive acidification of the extracellular milieu by lactic acid protons. Together, data suggest that neutralizing the effects of intratumoral acidity while maintaining physiological lactate metabolism in cytotoxic CD8 T cells should be pursued to boost anti-tumor immunity.
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