来自杂志 Theranostics 的文献。
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惊鸿
(2023-08-28 23:29):
#paper DOI : 10.7150/thno.82228 2023-06-12 Lipid nanoparticles-loaded with toxin mRNA represents a new strategy for the treatment of solid tumors.
癌症治疗在过去十年中取得了显着发展，提供了使用免疫调节抑制癌细胞生长的新策略，无论是否使用基因治疗。具体而言，已经研究了自杀基因疗法和免疫毒素通过直接癌细胞细胞毒性治疗肿瘤。mRNA递送的最新进展也证明了基于mRNA的疫苗和免疫调节剂通过利用纳米载体进行mRNA递送而具有癌症治疗的潜力。
Abstract:
: Cancer therapy have evolved remarkably over the past decade, providing new strategies to inhibit cancer cell growth using immune modulation, with or without gene therapy. Specifically, suicide gene therapies …
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: Cancer therapy have evolved remarkably over the past decade, providing new strategies to inhibit cancer cell growth using immune modulation, with or without gene therapy. Specifically, suicide gene therapies and immunotoxins have been investigated for the treatment of tumors by direct cancer cell cytotoxicity. Recent advances in mRNA delivery also demonstrated the potential of mRNA-based vaccines and immune-modulators for cancer therapeutics by utilizing nanocarriers for mRNA delivery. We designed a bacterial toxin-encoding modified mRNA, delivered by lipid nanoparticles into a B16-melanoma mouse model. : We showed that local administration of LNPs entrapping a modified mRNA that encodes for a bacterial toxin, induced significant anti-tumor effects and improved overall survival of treated mice. We propose mmRNA-loaded LNPs as a new class of anti-tumoral, toxin-based therapy.
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