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惊鸿
(2023-01-07 21:44):
#paper DOI : 10.1038/s43587-022-00340-7 Pub Date:2022-12-30Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan 线粒体功能障碍在衰老中起着核心作用，但确切的生物学原因仍在确定中。在这里，我们展示了使用光激活质子泵在成年期通过光遗传学增加线粒体膜电位可改善与年龄相关的表型并延长秀丽隐杆线虫的寿命。我们的研究结果提供了直接的因果证据，表明挽救与年龄相关的线粒体膜电位下降足以减缓衰老速度并延长健康寿命和寿命。
Abstract:
Mitochondrial dysfunction plays a central role in aging but the exact biological causes are still being determined. Here, we show that optogenetically increasing mitochondrial membrane potential during adulthood using a …
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Mitochondrial dysfunction plays a central role in aging but the exact biological causes are still being determined. Here, we show that optogenetically increasing mitochondrial membrane potential during adulthood using a light-activated proton pump improves age-associated phenotypes and extends lifespan in . Our findings provide direct causal evidence that rescuing the age-related decline in mitochondrial membrane potential is sufficient to slow the rate of aging and extend healthspan and lifespan.
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