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LXJ
(2023-04-28 11:33):
#paper RhoB affects colitis through modulating cell signaling and intestinal microbiome.Microbiome, 2022 Sep 16;10(1). DOI：10.1186/s40168-022-01347-3. 背景：炎症性肠病（IBD）的发病机制是多因素的，IBD的诊断和治疗策略仍有待制定。RhoB调节多种细胞功能；然而，它在结肠炎中的作用尚未被探索。
结果：本文中研究者发现溃疡性结肠炎（UC）患者和DSS诱导的结肠炎小鼠的结肠组织中RhoB显著增加。与野生型小鼠相比，RhoB和RhoB小鼠发生了较轻的DSS诱导的结肠炎，杯状细胞数量和IEC增殖增加。RhoB降低通过抑制Wnt信号通路和激活p38 MAPK信号通路促进杯状细胞分化和上皮再生。此外，在RhoB和RhoB小鼠的肠道微生物组中检测到SCFA产生菌和SCFA浓度增加，并且还观察到SCFA受体表达上调。
结论：总之，较高水平的RhoB与UC有关，UC也通过调节细胞信号传导和改变肠道细菌组成和代谢产物来促进UC的发展。这些观察结果表明，RhoB具有作为UC的生物标志物和治疗靶点的潜力。
Abstract:
BACKGROUND: The pathogenesis of inflammatory bowel diseases (IBD) is multifactorial, and diagnostic and treatment strategies for IBD remain to be developed. RhoB regulates multiple cell functions; however, its role in …
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BACKGROUND: The pathogenesis of inflammatory bowel diseases (IBD) is multifactorial, and diagnostic and treatment strategies for IBD remain to be developed. RhoB regulates multiple cell functions; however, its role in colitis is unexplored.RESULTS: Here, we found RhoB was dramatically increased in colon tissues of ulcerative colitis (UC) patients and mice with DSS-induced colitis. Compared with wild type mice, RhoB+/- and RhoB-/- mice developed milder DSS-induced colitis and increased goblet cell numbers and IEC proliferation. Decreased RhoB promoted goblet cell differentiation and epithelial regeneration through inhibiting Wnt signaling pathway and activating p38 MAPK signaling pathway. Moreover, increased SCFA-producing bacteria and SCFA concentrations were detected in intestinal microbiome of both RhoB+/- and RhoB-/- mice and upregulated SCFA receptor expression was also observed.CONCLUSIONS: Taken together, a higher level of RhoB is associated with UC, which also contributes to UC development through modulating cell signaling and altering intestinal bacterial composition and metabolites. These observations suggest that RhoB has potential as a biomarker and a treatment target for UC. Video Abstract.
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