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cellsarts
(2023-01-01 00:01):
#paper 古生菌信号肽酶DOI 10.1099/mic.0.2006/003087-0;Microbiology (2007), 153, 305–314
古生菌构成了生命的第三个领域，不同于
细菌和真核生物。最初被认为只生活在极端环境中，古细菌
物种自此被发现种类繁多，种类繁多栖息地，它们在生态系统中扮演着重要的角色
。信号肽酶是蛋白质分泌途径中的重要酶。在古生菌中，I型信号
肽酶，负责从大部分分泌的信号肽中切割分泌信号肽
蛋白质和类前肽肽酶信号肽酶负责处理信号肽
像前鞭毛蛋白和各种糖结合蛋白一样的前鞭毛蛋白
识别。此外，古菌的信号肽肽酶，负责信号的降解。这些酶似乎
具有真核和细菌的镶嵌特征，同时也具有独特的古菌
特征。综述总结了关于这些酶的最新知识，
包括它们的细胞功能、催化机制以及在其中的分布和保存
古细菌物种。将这些酶与它们的细菌酶和真核酶进行比较
对应物和独特的古菌特征突出。
Abstract:
Signal peptidases are vital enzymes in the protein secretion pathway. In Archaea, type I signal peptidase, responsible for the cleavage of secretory signal peptides from the majority of secreted proteins, …
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Signal peptidases are vital enzymes in the protein secretion pathway. In Archaea, type I signal peptidase, responsible for the cleavage of secretory signal peptides from the majority of secreted proteins, and prepilin peptidase-like signal peptidase, responsible for processing signal peptides from prepilin-like proteins like the preflagellins and various sugar-binding proteins, have been identified. In addition, the archaeal signal peptide peptidase, responsible for degradation of signal peptides after their removal from precursor proteins, has been characterized. These enzymes seem to have a mosaic of eukaryal and bacterial characteristics, and also possess unique archaeal traits. In this review, the most current knowledge with regard to these enzymes is summarized, including their cellular function, catalytic mechanism and distribution and conservation among archaeal species. Comparisons are drawn of these enzymes to their bacterial and eukaryal counterparts, and unique archaeal features highlighted.
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