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周周复始 (2022-11-30 21:53):
#paper https://doi.org/10.1007/978-3-031-17117-8_4 Chen, L., Wu, J., Wu, Q., Wei, H., Zhang, Y. (2022). Continuous Longitudinal Fetus Brain Atlas Construction via Implicit Neural Representation. In: Licandro, R., Melbourne, A., Abaci Turk, E., Macgowan, C., Hutter, J. (eds) Perinatal, Preterm and Paediatric Image Analysis. PIPPI 2022. Lecture Notes in Computer Science, vol 13575. Springer, Cham. 纵向胎儿脑图谱是了解和表示胎儿大脑复杂发育过程的工具。现有的胎儿脑图谱的创建通常是平均每个时间的脑模版,时间点也是离散的。但由于样本在不同时间点的个体遗传趋势不同,所得到的图谱存在时间上的不一致性,可能导致大脑发育特征参数在时间轴上出现误差。因此本文提出了一个多阶段深度学习框架来解决时间不一致性的问题,将时间不一致性问题转换为4D图像数据去噪任务。利用隐式神经表示,创建了连续无噪声的胎儿纵向脑图谱,并将其作为4D时空坐标函数。并用两个公开的胎儿大脑图谱(CRL和FBA-Chinese图谱)做实验。结果表明,该方法在保留胎儿大脑结构表示的同时,显著提高了图谱的时间一致性。此外,连续的胎儿纵向脑图谱可广泛应用于生成更精细的4D时空分辨率图谱。
Abstract:
Longitudinal fetal brain atlas is a powerful tool for understanding and characterizing the complex process of fetus brain development. Existing fetus brain atlases are typically constructed by averaged brain images … >>>
Longitudinal fetal brain atlas is a powerful tool for understanding and characterizing the complex process of fetus brain development. Existing fetus brain atlases are typically constructed by averaged brain images on discrete time points independently over time. Due to the differences in onto-genetic trends among samples at different time points, the resulting atlases suffer from temporal inconsistency, which may lead to estimating error of the brain developmental characteristic parameters along the timeline. To this end, we proposed a multi-stage deep-learning framework to tackle the time inconsistency issue as a 4D (3D brain volume + 1D age) image data denoising task. Using implicit neural representation, we construct a continuous and noise-free longitudinal fetus brain atlas as a function of the 4D spatial-temporal coordinate. Experimental results on two public fetal brain atlases (CRL and FBA-Chinese atlases) show that the proposed method can significantly improve the atlas temporal consistency while maintaining good fetus brain structure representation. In addition, the continuous longitudinal fetus brain atlases can also be extensively applied to generate finer 4D atlases in both spatial and temporal resolution. <<<
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