来自杂志 Journal of biophotonics 的文献。
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(2022-07-26 23:37):
#paper doi:10.1002/jbio.202100389 Journal of Biophotonics, 2022, Skin's green autofluorescence at dorsal centremetacarpus may become a novel biomarker for diagnosis of lung cancer. 肿瘤早筛是当下最热门的研发方向之一，过热到都似乎开始裁员的地步，因为大家都在同质化地走类似的路线（如甲基化测序）。而这篇来自上海交大的文章，另辟蹊径地采取对皮肤的自发荧光进行检测的方法，尝试将其用于肺癌早期筛查和诊断。这是一种真正无创的新型检测方法，其原理在于皮肤表皮的棘层中，存在一种角蛋白分子，在蓝光照射下会发出荧光。而这种荧光的强度，又与疾病状态相关。本文研究中纳入了临床实际病例和异体移植的小鼠肿瘤模型，从肺部感染或健康对照中分别区分肺癌，AUC分别可达到 0.871 和 0.813，证明了这是一种潜在的生物标志物，可用于肺癌早期筛查和诊断。
Abstract:
It is critical to discover novel biomarkers of lung cancer for establishing economical technology for diagnosis of lung cancer. Our study has suggested that the autofluorescence (AF) of the skin …
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It is critical to discover novel biomarkers of lung cancer for establishing economical technology for diagnosis of lung cancer. Our study has suggested that the autofluorescence (AF) of the skin may become a novel biomarker of this type: First, development of lung cancer led to a significant increase in the skin's green AF in a mouse model of lung cancer; second, lung cancer patients had significantly higher skin's green AF at certain positions compared with healthy volunteers and pulmonary infection patients; and third, using the skin's green AF intensity at dorsal centremetacarpus as the variable, the areas under curve (AUC) for differentiating lung cancer patients and pulmonary infection patients and for differentiating lung cancer patients and healthy volunteers was 0.871 and 0.813, respectively. Collectively, our study has indicated that the skin's green AF at dorsal centremetacarpus may become a novel biomarker for establishing a ground-breaking diagnostic strategy for lung cancer.
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