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DWBin
(2022-08-31 20:47):
#paper https://journals.sagepub.com/doi/10.4137/BBI.S7003 Gene Networks Driving Bovine Mammary Protein Synthesis during the Lactation cycle 作者对乳蛋白合成机制和基因差异表达进行了研究，绘制了乳蛋白基因调控表达网络图。乳蛋白基因的表达受到多个因素调控是个复杂的生物学过程，主要包括氨基酸转运系统、蛋白酪氨酸激酶2信号转导子和转录激活子5信号转导途径和雷帕霉素靶蛋白信号通路。
Abstract:
A crucial role for both insulin and mTOR in the regulation of milk protein synthesis is emerging. Bovine mammary biopsies harvested during late-pregnancy through end of subsequent lactation were used …
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A crucial role for both insulin and mTOR in the regulation of milk protein synthesis is emerging. Bovine mammary biopsies harvested during late-pregnancy through end of subsequent lactation were used to evaluate via quantitative PCR the expression of 44 genes involved in pathways of insulin, mTOR, AMPK, and Jak2-Stat5 signalling and also glucose and amino acid (AA) transporters. We observed an increased expression during lactation of ELF5, AA and glucose transporters, insulin signaling pathway components, MAPK14, FRAP1, EIF4EBP2, GSK3A and TSC1 among mTOR signaling-related genes. Among ribosomal components RPL22 was down-regulated. The overall data support a central role of AA and glucose transporters and insulin signaling through mTOR for the regulation of protein synthesis in bovine mammary gland. Furthermore, the existence of translational competition favoring the translation of milk protein transcripts was inferred from the combined dataset.
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