AI 5.0.3
(2023-03-31 20:44):
#paper 主要内容:快速伽马震荡精准协调上下神经系统,分别从海马外内侧收集神经元信息传入海马实现在物体识别和方位判断的作用。主要结论:空间导航中快伽马震荡协调齿状回和MEC,慢伽马震荡协调齿状回和LEC,MEC和LEC的信息以伽马周期对任务进行特异性选择。A. Fernández-Ruiz et al., Science 372, eabf3119 (2021). DOI: 10.1126/science.abf3119
Gamma rhythm communication between entorhinal cortex and dentate gyrus neuronal assemblies
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Abstract:
Gamma oscillations are thought to coordinate the spike timing of functionally specialized neuronal ensembles across brain regions. To test this hypothesis, we optogenetically perturbed gamma spike timing in the rat medial (MEC) and lateral (LEC) entorhinal cortices and found impairments in spatial and object learning tasks, respectively. MEC and LEC were synchronized with the hippocampal dentate gyrus through high- and low-gamma-frequency rhythms, respectively, and engaged either granule cells or mossy cells and CA3 pyramidal cells in a task-dependent manner. Gamma perturbation disrupted the learning-induced assembly organization of target neurons. Our findings imply that pathway-specific gamma oscillations route task-relevant information between distinct neuronal subpopulations in the entorhinal-hippocampal circuit. We hypothesize that interregional gamma-time-scale spike coordination is a mechanism of neuronal communication.
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