颜林林
(2023-03-02 07:38):
#paper doi:10.1016/j.csbj.2023.02.016 Computational and Structural Biotechnology Journal, 2023, DNAsmart: Multiple attribute ranking tool for DNA data storage systems. 将DNA用作存储介质,已经逐渐成为一个热门的研究方向。由于DNA在读取(测序)和写入(合成)过程中,受到其自身特性和其他环境体系不同因素的影响,存在各类错误。这篇研究提供了一个网站工具DNAsmart,以交互式的方式,可视化地展示核酸片段之间诸如GC含量、汉明距离等不同属性,帮助研究者探索如何有效利用和平衡这些属性的影响,以设计出更合适的DNA存储的编解码方案。
IF:4.400Q2
Computational and structural biotechnology journal,
2023.
DOI: 10.1016/j.csbj.2023.02.016
PMID: 36851917
PMCID:PMC9957737
DNAsmart: Multiple attribute ranking tool for DNA data storage systems
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Abstract:
In an ever-growing need for data storage capacity, the Deoxyribonucleic Acid (DNA) molecule gains traction as a new storage medium with a larger capacity, higher density, and a longer lifespan over conventional storage media. To effectively use DNA for data storage, it is important to understand the different methods of encoding information in DNA and compare their effectiveness. This requires evaluating which decoded DNA sequences carry the most encoded information based on various attributes. However, navigating the field of coding theory requires years of experience and domain expertise. For instance, domain experts rely on various mathematical functions and attributes to score and evaluate their encodings. To enable such analytical tasks, we provide an interactive and visual analytical framework for multi-attribute ranking in DNA storage systems. Our framework follows a three-step view with user-settable parameters. It enables users to find the optimal en-/de-coding approaches by setting different weights and combining multiple attributes. We assess the validity of our work through a task-specific user study on domain experts by relying on three tasks. Results indicate that all participants completed their tasks successfully under two minutes, then rated the framework for design choices, perceived usefulness, and intuitiveness. In addition, two real-world use cases are shared and analyzed as direct applications of the proposed tool. DNAsmart enables the ranking of decoded sequences based on multiple attributes. In sum, this work unveils the evaluation of en-/de-coding approaches accessible and tractable through visualization and interactivity to solve comparison and ranking tasks.
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