Arwen (2022-10-31 23:28):
#paper https://doi.org/10.1016/j.neuroimage.2021.118799 Longitudinal brain atlases of early developing cynomolgus macaques from birth to 48 months of age 具有密集采样时间点和解剖信息的纵向脑图谱对研究人类和非人类灵长类动物婴儿期大脑的早期发育特征具有重要意义。然而,对于非人类灵长类动物这种对于理解人类大脑有极大帮助的动物模型来说,现有的大脑图谱主要是基于成人或青少年的,明显能够覆盖早期脑发育阶段的密集脑图谱。为填补这一空白,作者团队基于39只食蟹猴的175个纵向MRI数据,构建了一套纵向的脑图谱和组织分割概率图,共包含从出生到4岁(即1、2、3、4、5、6、9、12、18、24、36和48月龄)的12个时间点。
Longitudinal brain atlases of early developing cynomolgus macaques from birth to 48 months of age
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Abstract:
Longitudinal brain imaging atlases with densely sampled time-points and ancillary anatomical information are of fundamental importance in studying early developmental characteristics of human and non-human primate brains during infancy, which feature extremely dynamic imaging appearance, brain shape and size. However, for non-human primates, which are highly valuable animal models for understanding human brains, the existing brain atlases are mainly developed based on adults or adolescents, denoting a notable lack of temporally densely-sampled atlases covering the dynamic early brain development. To fill this critical gap, in this paper, we construct a comprehensive set of longitudinal brain atlases and associated tissue probability maps (gray matter, white matter, and cerebrospinal fluid) with totally 12 time-points from birth to 4 years of age (i.e., 1, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, and 48 months of age) based on 175 longitudinal structural MRI scans from 39 typically-developing cynomolgus macaques, by leveraging state-of-the-art computational techniques tailored for early developing brains. Furthermore, to facilitate region-based analysis using our atlases, we also provide two popular hierarchy parcellations, i.e., cortical hierarchy maps (6 levels) and subcortical hierarchy maps (6 levels), on our longitudinal macaque brain atlases. These early developing atlases, which have the densest time-points during infancy (to the best of our knowledge), will greatly facilitate the studies of macaque brain development.
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