2022,
Cytokine.
DOI:
10.1016/j.cyto.2022.155874
Pro-inflammatory immune profile mediated by TNF and IFN-γ and regulated by IL-10 is associated to IgG anti-SARS-CoV-2 in asymptomatic blood donors
Daniel Gonçalves Chaves, Leonardo Camilo de Oliveira, Maria Clara Fernandes da Silva Malta, Isabelle Rocha de Oliveira, Edel Figueiredo Barbosa-Stancioli, Mauro Martins Teixeira, Marina Lobato Martins
Abstract:
No abstract available.
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2023-10-25 12:35:00
龙海晨:
#paper Chaves DG, de Oliveira LC, da Silva Malta MCF, de Oliveira IR, Barbosa-Stancioli EF, Teixeira MM, Martins ML. Pro-inflammatory immune profile mediated by TNF and IFN-γ and regulated by IL-10 is associated to IgG anti-SARS-CoV-2 in asymptomatic blood donors. Cytokine. 2022 Jun;154:155874. doi: 10.1016/j.cyto.2022.155874. Epub 2022 Apr 4. PMID: 35397248; PMCID: PMC8977499.
文章是巴西在新冠时期做的研究，对7837名献血者做的研究检测血液中的抗体水平。发现症状严重的TNF、IFN-γ和IL-10浓度较高。症状的严重程度与IgG抗体的中和能力有关。而IgG抗体的中和能力和血清的CCL5和CXCL10显著相关。文章据此假设维持在IL-10调节良好的促炎微环境中可以提高对新冠的免疫适应性。