2023,
Infection and Immunity.
DOI:
10.1128/iai.00037-23
Identification of Virulence Factors Involved in a Murine Model of Severe Achromobacter xylosoxidans Infection
Brandon M. Wills
, Preeti Garai
, Molly O. Riegert
, Felix T. Sanchez
, Adam M. Pickrum
, Dara W. Frank
, Kenneth L. Brockman
Abstract:
Achromobacter xylosoxidans
(Ax) is an opportunistic pathogen and causative agent of numerous infections particularly in immunocompromised individuals with increasing prevalence in cystic fibrosis (CF). To date, investigations have focused on the clinical epidemiology and genomic comparisons of Ax isolates, yet little is known about disease pathology or the role that specific virulence factors play in tissue invasion or damage.
(Ax) is an opportunistic pathogen and causative agent of numerous infections particularly in immunocompromised individuals with increasing prevalence in cystic fibrosis (CF). To date, investigations have focused on the clinical epidemiology and genomic comparisons of Ax isolates, yet little is known about disease pathology or the role that specific virulence factors play in tissue invasion or damage.
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2023-07-30 10:58:00
钟鸣:
#paper doi：10.1128/iai.00037-23 Identification of Virulence Factors Involved in a Murine Model of Severe Achromobacter xylosoxidans Infection
本文使用正常鼠、免疫低下鼠、正常毒株、弱毒株进行攻毒实验，以此研究木糖氧化无色杆菌(Ax)的毒力影响因素。核心结论是，插入突变研究结果表明， III 型分泌系统、Vi 胶囊、antisigma-E 因子，以及ArtA 粘附素是影响毒力强弱的主要因素。