2023,
Pharmaceuticals.
DOI:
10.3390/ph16030328
Chemical Composition and Antimicrobial Potential of a Plant-Based Substance for the Treatment of Seborrheic Dermatitis
Viktor A. Filatov
, Olesya Yu. Kulyak
, Elena I. Kalenikova
Abstract:
Seborrheic dermatitis (SD) is the most prevalent dermatological disease, occurring in up to 50% of newborns, children, and adults around the world. The antibacterial and antifungal resistance contributed to the search for new natural substances and the development of a novel substance based on Melaleuca alternifolia (M. alternifolia) leaf oil (TTO), 1,8-cineole (eucalyptol), and α-(-)-bisabolol. Thus, this work aimed to determine the chemical composition of the novel plant-based substance and to evaluate its antimicrobial activity against standard microorganisms involved in the pathogenesis of SD. Moreover, the chemical composition of the substance was analyzed by gas chromatography coupled with mass spectrometry (GC/MS). Staphylococcus epidermidis (S. epidermidis), Staphylococcus aureus (S. aureus), Micrococcus luteus (M. luteus), and Candida albicans (C. albicans) were used for antimicrobial and antifungal assays by means of the broth microdilution method to determine the minimal inhibitory concentration (MIC). Finally, the substance’s ability to inhibit Malassezia furfur (M. furfur) was evaluated. Eighteen compounds from different chemical groups were identified by GC/MS. The major biologically active compounds of the substance were terpinen-4-ol (20.88%), 1,8-cineole (22.28%), (-)-α-bisabolol (25.73%), and o-cymene (8.16%). The results showed that the substance has a synergistic antimicrobial and antifungal activity, while S. epidermidis and C. albicans strains were the most susceptible. Furthermore, the substance inhibited M. furfur, which is a main pathogen involved in the pathogenesis of SD and clinical manifestations. It can be concluded that the novel plant-based substance has a promising potential against M. furfur and scalp commensal bacteria and may be helpful for the development of new drugs for treatment of dandruff and SD.
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2023-04-28 17:27:00
钟鸣:
#paper doi：10.3390/ph16030328 Chemical Composition and Antimicrobial Potential of a Plant-Based Substance for the Treatment of Seborrheic Dermatitis
脂溢性皮炎 (SD) 是最常见的头皮皮肤病，全世界高达 50% 的成年人都会发生。SD的发生与多种因素有关，但确切的发病机制仍未阐明。目前对SD的治疗以抗真菌和抗炎为主，但长期使用这类药物不仅有引起副作用的风险，真菌耐药性的诱导也是不可忽视的风险之一，为此作者将目光投向了植物源药物，即本文中的互叶白千层叶油（TTO）。作者首先使用GS/MS分析了成分，确定了 TTO 特有的 10 种抗菌单萜和倍半萜以及以前未在 TTO 中检测到的 7 种新萜。随后的抑菌试验和抗真菌实验表明这种物质的抗菌活性与苯扎氯铵、酮康唑和氯咪唑相当；因此，该物质有望用于进一步研究和评估可能用于治疗 SD 的药物开发。