2023,
Cell Stem Cell.
DOI:
10.1016/j.stem.2023.09.014
Decoding aging-dependent regenerative decline across tissues at single-cell resolution
Yusheng Cai, Muzhao Xiong, Zijuan Xin, Chengyu Liu, Jie Ren, Xiying Yang, Jinghui Lei, Wei Li, Feifei Liu, Qun Chu, Yiyuan Zhang, Jian Yin, Yanxia Ye, Dingyi Liu, Yanling Fan, Shuhui Sun, Yaobin Jing, Qian Zhao, Liyun Zhao, Shanshan Che, Yandong Zheng, Haoteng Yan, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Abstract:
No abstract available.
Related Links:
2023-10-31 23:52:00
小W:
#paper doi：10.1016/j.stem.2023.09.014 Decoding aging-dependent regenerative decline across tissues at single-cell resolution 本文主要讲述了衰老对组织损伤修复的的影响，作者构建了小鼠的八个不同组织损伤模型，对年轻和衰老小鼠的损伤前、修复开始、修复进展和修复消退四个阶段，进行单细胞转录组分析，绘画不同年纪、损伤修复阶段和组织独特和共享的基因特征和细胞特征。本文主要的两个观点：衰老和年轻小鼠在损伤修复时激活不同 MuSC 亚型的干细胞，衰老MuSC 亚型的干细胞具有较弱的分化能力；Arg1+ 巨噬细胞在各种组织的再生和修复中激增，衰老小鼠 Arg1+ 巨噬细胞受到削弱，其可能通过影响血管生成能力,，导致衰老个体损伤修复能力的衰退。