惊鸿 (2022-11-28 10:33):
#paper CRISPRing future medicinesExpert Opin. Drug Discov.PubDate:2021-01-03DOI:10.1080/17460441.2021.1850687Laure Grand Moursel 1 , Mijke Visser 1 , Geraldine Servant 1 , Selvi Durmus 1 , Anne-Marie Zuurmond 1这是以快速且具有成本效益的方式设计哺乳动物基因组的能力导致 CRISPR 技术在生物医学研究中的快速适应。基于 CRISPR 的工程具有加速药物发现、支持降低药物开发中的高损耗率以及促进细胞和基因疗法的开发的潜力。CRISPR 技术正迅速成为基因组工程的首选工具,如今很难想象没有这项技术的药物发现管道。随着未来几年,CRISPR 技术无疑将得到进一步完善,并将蓬勃发展成为一项成熟的技术,它将在支持药物发现管道以及细胞和基因治疗开发中的基因组工程要求方面发挥关键作用。
CRISPRing future medicines
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Abstract:
: The ability to engineer mammalian genomes in a quick and cost-effective way has led to rapid adaptation of CRISPR technology in biomedical research. CRISPR-based engineering has the potential to accelerate drug discovery, to support the reduction of high attrition rate in drug development and to enhance development of cell and gene-based therapies.: How CRISPR technology is transforming drug discovery is discussed in this review. From target identification to target validation in both and models, CRISPR technology is positively impacting the early stages of drug development by providing a straightforward way to genome engineering. This property also attracted attention for CRISPR application in the cell and gene therapy area.: CRISPR technology is rapidly becoming the preferred tool for genome engineering and nowadays it is hard to imagine the drug discovery pipeline without this technology. With the years to come, CRISPR technology will undoubtedly be further refined and will flourish into a mature technology that will play a key role in supporting genome engineering requirements in the drug discovery pipeline as well as in cell and gene therapy development.
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