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2020, Schizophrenia Bulletin. DOI: 10.1093/schbul/sbaa155
Disrupted Intersubject Variability Architecture in Functional Connectomes in Schizophrenia
Xiaoyi Sun, Jin Liu, Qing Ma, Jia Duan, Xindi Wang, Yuehua Xu, Zhilei Xu, Ke Xu, Fei Wang, Yanqing Tang, Yong He, Mingrui Xia
Abstract:
Abstract
Schizophrenia (SCZ) is a highly heterogeneous disorder with remarkable intersubject variability in clinical presentations. Previous neuroimaging studies in SCZ have primarily focused on identifying group-averaged differences in the brain connectome between patients and healthy controls (HCs), largely neglecting the intersubject differences among patients. We acquired whole-brain resting-state functional MRI data from 121 SCZ patients and 183 HCs and examined the intersubject variability of the functional connectome (IVFC) in SCZ patients and HCs. Between-group differences were determined using permutation analysis. Then, we evaluated the relationship between IVFC and clinical variables in SCZ. Finally, we used datasets of patients with bipolar disorder (BD) and major depressive disorder (MDD) to assess the specificity of IVFC alteration in SCZ. The whole-brain IVFC pattern in the SCZ group was generally similar to that in HCs. Compared with the HC group, the SCZ group exhibited higher IVFC in the bilateral sensorimotor, visual, auditory, and subcortical regions. Moreover, altered IVFC was negatively correlated with age of onset, illness duration, and Brief Psychiatric Rating Scale scores and positively correlated with clinical heterogeneity. Although the SCZ shared altered IVFC in the visual cortex with BD and MDD, the alterations of IVFC in the sensorimotor, auditory, and subcortical cortices were specific to SCZ. The alterations of whole-brain IVFC in SCZ have potential implications for the understanding of the high clinical heterogeneity of SCZ and the future individualized clinical diagnosis and treatment of this disease.
2023-10-31 11:57:00
#paper doi:10.1093/schbul/sbaa155 Disrupted Intersubject Variability Architecture in Functional Connectomes in Schizophrenia 精神分裂症是一种高度异质性的疾病,临床表现存在个体差异。 先前在精分进行的神经影像学研究主要集中于识别患者和健康对照 (HC) 之间大脑连接组的组平均差异,忽略了被试间差异。 作者获取了 121 名 精分患者和 183 名 HC 的全脑静息态功能 MRI 数据,并检查了 患者和 HC 功能连接组的个体间差异。 然后,作者评估了 个体间差异 与 患者 临床变量之间的关系。 患者 组的全脑个体间差异模式与 HC 组基本相似。 与HC组相比,精分组在双侧感觉运动、视觉、听觉和皮质下区域表现出更高的个体间差异。 此外,个体间差异的改变与发病年龄、病程和简明精神病评定量表评分呈负相关,与临床异质性呈正相关。 精分中全脑个体间差异的改变对于理解 精分的高度临床异质性以及该疾病未来的个体化临床诊断和治疗具有潜在的意义。
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