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李翛然 (2024-03-31 01:07):
#paper doi:doi.org/10.1021/acs.analchem.2c05065 RETURN TO ISSUEPREVARTICLENEXT Simultaneous Dual-Wavelength Source Raman Spectroscopy with a Handheld Confocal Probe for Analysis of the Chemical Composition of In Vivo Human Skin 介绍了一种便携式共焦拉曼光谱系统,具有同时双波长光源和迷你手持探头,用于分析体内人体皮肤的化学成分。该系统能够同时获取指纹区(450−1750 cm−1)和高波数区(2800−3800 cm−1)的光谱,解决了当前商用CRS系统的局限性。关键点包括创新设计结合671和785 nm激光、精确的拉曼光谱分离算法(PRSSA)用于解耦FP和HW光谱,以及数据采集时间减少超过50%。该系统在快速和超宽带光谱采集方面表现出色,显示了在临床工作流程中整合CRS的潜力。 最近可能搞个拉曼光谱仪做美容
IF:6.700Q1 Analytical chemistry, 2023-03-28. DOI: 10.1021/acs.analchem.2c05065 PMID: 36930570
Abstract:
Confocal Raman spectroscopy (CRS) is a powerful tool that has been widely used for biological tissue analysis because of its noninvasive nature, high specificity, and rich biochemical information. However, current … >>>
Confocal Raman spectroscopy (CRS) is a powerful tool that has been widely used for biological tissue analysis because of its noninvasive nature, high specificity, and rich biochemical information. However, current commercial CRS systems suffer from limited detection regions (450-1750 cm), bulky sizes, nonflexibilities, slow acquisitions by consecutive excitations, and high costs if using a Fourier transform (FT) Raman spectroscopy with an InGaAs detector, which impede their adoption in clinics. In this study, we developed a portable CRS system with a simultaneous dual-wavelength source and a miniaturized handheld probe (120 mm × 60 mm × 50 mm) that can acquire spectra in both fingerprint (FP, 450-1750 cm) and high wavenumber (HW, 2800-3800 cm) regions simultaneously. An innovative design combining 671 and 785 nm lasers for simultaneous excitation through a compact and high-efficiency (>90%) wavelength combiner was implemented. Moreover, to decouple the fused FP and HW spectra, a first-of-its-kind precise Raman spectra separation algorithm (PRSSA) was developed based on the maximum probability (MAP) estimate. The accuracy of spectra separation was greater than 99%, demonstrated in both phantom experiments and human skin measurements. The total data acquisition time was reduced by greater than 50% compared to other CRS systems. The results proved our proposed CRS system and PRSSA's superior capability in fast and ultrawideband spectra acquisition will significantly improve the integration of CRS in the clinical workflow. <<<
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